中性粒细胞和神经突生长在周围神经系统

Uwe Ernsberger, Hermann Rohrer
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引用次数: 3

摘要

在这篇综述中,我们总结了中性粒细胞参与周围神经系统神经突生长调节的证据。最近的研究表明,许多处于早期发育阶段的神经元在体外通过增加存活和形态分化来响应NT3。此外,NT3 mRNA也可以在胚胎组织中检测到。在发育后期,NT3反应可能丢失并被NGF反应所取代。这些数据表明,不同体外发育的周围神经元可以区分出早期的ngf不依赖期、nt3敏感期和晚期的ngf响应期,并提出了在体内不同发育时期作用的不同中性粒细胞可能影响神经突生长的可能性。
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Neutrophins and neurite outgrowth in the peripheral nervous system

In this review we summarize evidence for the involvement of neutrophins in the regulation of neurite outgrowth in the peripheral nervous system. Recent studies have shown that many neurons at early developmental stages respond to NT3 by increased survival and morphological differentiation in vitro. In addition, NT3 mRNA can be detected at this time in embryonic tissues trespassed by outgrowing neurites. Later during development, the NT3 response may be lost and replaced by a NGF response. The data show that an early NGF-independent, NT3-sensitive and a late NGF-responsive period can be distinguished for different developing peripheral neurons in vitro and raise the possibility that neurite outgrowth may be influenced by the different neutrophins, acting at distinct developmental periods in vivo.

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