来自BJOG外部的见解

A. Kent, S. Kirtley
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引用次数: 0

摘要

外科手术什么时候需要使用抗生素,使用频率如何?这些都是复杂但重要的问题,很少在个人、机构或国家层面面临,但澳大利亚发表了一篇关于这一主题的翔实文章(Ierano et al.)。美国医学杂志2019;2:e1915003)。研究人员从全国五分之一以上的医院收集数据,发现10-20%的住院抗生素处方用于外科抗菌预防,他们能够衡量药物的适当性。在近1万份程序性评估中,他们发现时间不正确和持续时间过长是最常见的错误,在他们掌握信息的案例中,大约有一半发生了这种错误。国家指南建议,一些清洁的程序不需要“覆盖”,并且在使用时,预防措施应该是单次剂量,当然不应该延长24小时或更长时间。值得注意的是,妇科外科医生的不正确使用率高于骨科外科医生(作为参照组)。这是一项开创性的工作,作者因其首创精神而受到赞扬。对抗菌素的管理对于防止抗生素耐药性的发展至关重要。一些国家制定了针对产科和妇科的关于抗菌药物预防的类型、时间和持续时间的指导方针或立场声明。如果这些得到推广,它们可能会鼓励个人遵守我们的专业,并可能激励其他人实现正确使用手术抗生素的更广泛目标。
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Insights from outside BJOG
When is antibiotic cover indicated for surgical procedures and how often is it used appropriately? These are complex but important questions that are seldom confronted at personal, institutional or national levels, but an informative article on the topic from Australia has been published (Ierano et al. JAMA Netw Open 2019;2:e1915003). Gathering data from more than onefifth of the country’s hospitals, the researchers showed that 10–20% of inpatient antibiotic prescriptions were for surgical antimicrobial prophylaxis and they were able to gauge the appropriateness of the medication. Of nearly 10 000 procedural assessments, they found incorrect timing and too long a duration were the most common errors, occurring in roughly half of the cases for which they had information. National guidelines suggest some clean procedures do not require ‘cover’ and that when used, prophylaxis should be a single dose and should certainly not be extended for 24 hours or longer. It was noted that gynaecological surgeons had higher rates of incorrect use than orthopaedic surgeons (used as the reference group). This is ground-breaking work, and the authors are commended for their initiative. The stewardship of antimicrobials is essential to guard against antibiotic-resistance development. Some countries have guidelines or position statements that are specific for obstetrics and gynaecology about the type, timing and duration of antimicrobial prophylaxis. If these were promoted, they may encourage individuals to conform within our speciality and could be an incentive to others to achieve the wider goal of correct antibiotic usage for surgery.
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