葡萄籽副产品生物活性化合物对断奶仔猪免疫和抗氧化反应的调节作用

I. Țăranu, I. Grosu, A. Gras, M. Palade, V. Chedea, D. Marin
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摘要

葡萄加工生产葡萄酒会产生各种各样的残留物(果渣和种子),这些残留物富含生物活性化合物(多酚等)。它们的生物学潜力已经在反刍动物营养中得到了证实,但在猪身上的研究却很少。本试验旨在分析饲粮中添加葡萄籽副产物对断奶仔猪生长性能、免疫和抗氧化功能的影响。试验选取12头断奶仔猪,分别饲喂对照组和5%葡萄籽饼(GS)饲粮,饲喂30 d。30天后处死猪,采集血液和器官,-80°C保存,待分析。结果表明,饲粮中添加GS对猪生产性能无显著影响,但通过降低肝脏中TNF-α、IL-6、IFN-γ等炎性分子的基因表达而产生抗炎作用。对肝脏中抗氧化酶和丙二醛的活性和基因表达没有影响。对脾脏炎症的影响不明显,但抗氧化酶活性略有增加。综上所述,饲粮中添加GS可调节断奶仔猪的差异免疫和抗氧化反应。
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MODULATION OF IMMUNE AND ANTIOXIDANT RESPONSE IN WEANED PIGLETS BY BIOACTIVE COMPOUNDS FROM GRAPE SEED BY-PRODUCT
Grape processing for the production of wine generates a wide range of residues (pomace and seeds) rich in bioactive compounds (polyphenols, etc). Their biological potential has been already valorised in ruminant nutrition, but has been little investigated in pigs. This study was conducted to analyse the effect of dietary inclusion of grape seed by-product on growth performance, immune and antioxidant function in weaned pigs. A total of 12 weaned pigs were fed with a control or 5% grape seed cakes (GS) diets for 30 days. Pigs were sacrificed after 30 days, blood and organs were collected and stored at –80°C until analyses. The results showed that dietary GS did not exert significant effect on pig performance, but generated an anti-inflammatory effect by decreasing gene expression of TNF-α, IL-6, IFN-γ and other inflammatory molecules in liver. No effect on the activity and gene expression of antioxidant enzymes and malondialdehyde was also observed in liver. The effect on inflammation was less evident in spleen, but a slight increase in antioxidant enzyme activity was noticed. In conclusion, the dietary inclusion of GS modulated differentially immune and antioxidant response in weaned pig.
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