Chapter 6: Tuberculosis preventive treatment in adults

• Either once-weekly rifapentine and isoniazid for 3 months (3HP), or daily rifampin for 4 months (4R) is recommended. • When rifamycin based regimens cannot be used because they are not tolerated, not feasible or are contraindicated, the 9-month daily isoniazid regimen (9H) is the preferred option. • When the 9H regimen cannot be used, the six-month daily isoniazid regimen (6H) is recommended. • Evaluate for interactions between patients’ baseline medications and the prospective TPT regimen through an up-to-date drug decision support tool prior to treatment initiation.