δ -9-四氢大麻酚对狨猴帕金森模型的神经保护作用

Sanneke A. M. van Vliet, R. Vanwersch, M. Jongsma, J. Gugten, B. Olivier, I. Philippens
{"title":"δ -9-四氢大麻酚对狨猴帕金森模型的神经保护作用","authors":"Sanneke A. M. van Vliet, R. Vanwersch, M. Jongsma, J. Gugten, B. Olivier, I. Philippens","doi":"10.2174/1874143600701010013","DOIUrl":null,"url":null,"abstract":"The present medication in Parkinson's disease (PD) is unable to stop or slow down the progression of the dis- ease. Therefore pharmacological intervention at crucial steps in the neuronal cell death processes would be a better stra- tegy. Cannabinoids are potent neuroprotective compounds in models of oxidative stress and excitotoxicity and offer po- tential protection in models of PD. Therefore the present study determines the neuroprotective effects of � 9 - tetrahydrocannabinol (� 9 -THC) in the marmoset 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model on beha- vior and pathology. Twelve marmoset monkeys were treated with a total cumulative dose of 6 mg/kg MPTP in 9 days. Seven of these animals received simultaneously a daily oral dose of � 9 -THC (4 mg/kg) and five animals received simulta- neously vehicle for 27 days. The parkinsonian symptoms were observed daily and locomotor activity and hand-eye coor- dination were tested once a week during the experimental period. Postmortem, dopamine levels in the striatum were ana- lyzed and tyrosine hydroxylase immunohistochemistry was applied to determine viable dopaminergic neurons in the sub- stantia nigra. � 9 -THC has no protective effects on any parameter. These negative results might be related to the severity of the cell death induction by MPTP in relation to the low dose of � 9 -THC used in this Parkinson model.","PeriodicalId":22907,"journal":{"name":"The Open Pharmacology Journal","volume":"79 1","pages":"13-18"},"PeriodicalIF":0.0000,"publicationDate":"2007-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Neuroprotective Effects of Delta-9-Tetrahydrocannabinol in a Marmoset Parkinson Model\",\"authors\":\"Sanneke A. M. van Vliet, R. Vanwersch, M. Jongsma, J. Gugten, B. Olivier, I. Philippens\",\"doi\":\"10.2174/1874143600701010013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present medication in Parkinson's disease (PD) is unable to stop or slow down the progression of the dis- ease. Therefore pharmacological intervention at crucial steps in the neuronal cell death processes would be a better stra- tegy. Cannabinoids are potent neuroprotective compounds in models of oxidative stress and excitotoxicity and offer po- tential protection in models of PD. Therefore the present study determines the neuroprotective effects of � 9 - tetrahydrocannabinol (� 9 -THC) in the marmoset 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model on beha- vior and pathology. Twelve marmoset monkeys were treated with a total cumulative dose of 6 mg/kg MPTP in 9 days. Seven of these animals received simultaneously a daily oral dose of � 9 -THC (4 mg/kg) and five animals received simulta- neously vehicle for 27 days. The parkinsonian symptoms were observed daily and locomotor activity and hand-eye coor- dination were tested once a week during the experimental period. Postmortem, dopamine levels in the striatum were ana- lyzed and tyrosine hydroxylase immunohistochemistry was applied to determine viable dopaminergic neurons in the sub- stantia nigra. � 9 -THC has no protective effects on any parameter. These negative results might be related to the severity of the cell death induction by MPTP in relation to the low dose of � 9 -THC used in this Parkinson model.\",\"PeriodicalId\":22907,\"journal\":{\"name\":\"The Open Pharmacology Journal\",\"volume\":\"79 1\",\"pages\":\"13-18\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-10-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Pharmacology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874143600701010013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Pharmacology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874143600701010013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

目前治疗帕金森氏症(PD)的药物不能阻止或减缓疾病的进展。因此,在神经细胞死亡过程的关键阶段进行药物干预将是一种更好的策略。大麻素在氧化应激和兴奋性毒性模型中是有效的神经保护化合物,并在PD模型中提供潜在的保护。因此,本研究确定了- 9 -四氢大麻酚(- 9 - thc)在绒猴1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)模型中的神经保护作用。12只狨猴在9天内接受总累积剂量为6 mg/kg的MPTP治疗。其中7只动物同时接受每日口服剂量- 9 -四氢大麻酚(4mg /kg), 5只动物同时接受27天的载药。在实验期间,每天观察帕金森症状,每周检测一次运动活动和手眼协调能力。死后分析纹状体多巴胺水平,应用酪氨酸羟化酶免疫组化法测定黑质中活的多巴胺能神经元。9 -THC对任何参数都没有保护作用。这些阴性结果可能与MPTP诱导细胞死亡的严重程度有关,这与该帕金森模型中使用的低剂量- 9 -四氢大麻酚有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Neuroprotective Effects of Delta-9-Tetrahydrocannabinol in a Marmoset Parkinson Model
The present medication in Parkinson's disease (PD) is unable to stop or slow down the progression of the dis- ease. Therefore pharmacological intervention at crucial steps in the neuronal cell death processes would be a better stra- tegy. Cannabinoids are potent neuroprotective compounds in models of oxidative stress and excitotoxicity and offer po- tential protection in models of PD. Therefore the present study determines the neuroprotective effects of � 9 - tetrahydrocannabinol (� 9 -THC) in the marmoset 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model on beha- vior and pathology. Twelve marmoset monkeys were treated with a total cumulative dose of 6 mg/kg MPTP in 9 days. Seven of these animals received simultaneously a daily oral dose of � 9 -THC (4 mg/kg) and five animals received simulta- neously vehicle for 27 days. The parkinsonian symptoms were observed daily and locomotor activity and hand-eye coor- dination were tested once a week during the experimental period. Postmortem, dopamine levels in the striatum were ana- lyzed and tyrosine hydroxylase immunohistochemistry was applied to determine viable dopaminergic neurons in the sub- stantia nigra. � 9 -THC has no protective effects on any parameter. These negative results might be related to the severity of the cell death induction by MPTP in relation to the low dose of � 9 -THC used in this Parkinson model.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Single Time Heated Different Vegetable Oils Use-Impact on the Magnitude of Total Parenteral Nutrition (TPN) Associated Adverse Effects Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in Rats Evaluation of Acute Toxicity of the Methanolic Extract of Dhatryadi Ghrita in Wistar Rats Polysorbate 80 Coated Solid Lipid Nanoparticles for the Delivery of Temozolomide Into the Brain New Amino-steroid-anthracenone with Biological Activity Against Ischemia-reperfusion Injury in a Wistar Rat Model
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1