阿曼慢性乙型肝炎阳性患者肝活检中乙型肝炎表面抗原和乙型肝炎核心抗原表达模式与临床病理参数和抗病毒治疗的关系

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-06-30 DOI:10.13005/bpj/2683
Asma Mohammed Salim ALshuili, S. Al-Sinawi, R. Al-Ajmi, A. Shalaby, M. Mabruk
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引用次数: 0

摘要

背景:乙型肝炎病毒(HBV)感染被认为是一个主要的全球卫生问题。当前研究的主要目的是确定乙型肝炎表面抗原(HBsAg)和乙型肝炎核心抗原(HBcAg)在阿曼乙型肝炎病毒感染患者肝组织样本中的表达模式,并将HBsAg和HBcAg的表达模式与其他临床参数和抗病毒治疗联系起来。方法:采用免疫组化法(IHC)检测阿曼慢性乙型肝炎患者58例福尔马林固定石蜡包埋肝组织活检组织中HBsAg和HBV核心抗原HBcAg的表达规律。确定HBV抗原阳性与性别、年龄组、组织学表现和抗病毒治疗之间的关系。结果:28例(48.3%)患者HBsAg呈ihc阳性,其中4例(6.9%)患者HBcAg也有表达。在25例(89.3%)患者中,HBsAg以细胞质表达为主,而在3例(75%)患者中,HBcAg以核表达为主。男性HBsAg和HBcAg - IHC阳性高于女性,且39 ~ 58岁男性HBsAg和HBcAg - IHC阳性差异有统计学意义(P值分别为0.130和0.569)。在本研究中检查的大多数肝脏活检中存在淋巴细胞浸润,这表明肝脏损伤可能归因于免疫介导的事件,特别是因为HBV是一种非细胞致病性病毒。免疫组化检测HBsAg/HBcAg阳性与抗病毒治疗之间无显著统计学关联。结论:确定阿曼慢性乙型肝炎患者肝活检中HBV抗原的表达模式,以及这些表达模式与其他临床组织病理学参数和抗病毒治疗之间的关系,将极大地有助于更好地了解HBV在这一独特队列感染者群体中的发病机制。
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Association between the Expression Patterns of Hepatitis B Surface Antigen and Hepatitis B Core Antigen with Clinicopathological Parameters and Antiviral Therapy in Liver Biopsies Obtained from Chronically Infected Hepatitis B Positive Omani Patients
Background: Hepatitis B virus (HBV) infection is considered a major global health problem. The main objectives of the current study is to determine the patterns of expression of the hepatitis B surface antigen (HBsAg) and HBV core antigen (HBcAg) in liver tissue samples obtained from hepatitis B virus-infected Omani patients and to associate between the pattern of the expression of HBsAg and HBcAg with the other clinical parameters and anti-viral therapy. Methods : The expression patterns of HBsAg and HBV core antigen HBcAg were determined by immunohistochemistry (IHC), in 58 formalin-fixed paraffin-embedded liver tissue biopsies obtained from chronic hepatitis B Omani patients. The association between positivity for HBV antigens with gender, age group, histological appearances, and antiviral therapy was determined. Results: IHC-positive staining of HBsAg was demonstrated in 28 patients (48.3%) patients, of whom 4 (6.9%) also showed HBcAg expression. The expression pattern of HBsAg was predominantly cytoplasmic and was seen in 25 (89.3%) of patients, whereas expression of HBcAg was nuclear in 3 (75%) of patients. HBsAg and HBcAg IHC positivity were more common among males than females and among those aged 39–58 years (P = 0.130 and 0.569, respectively). The presence of lymphocytic infiltration in the majority of liver biopsies examined in the present study indicates that the liver damage could be attributed to immunologically mediated events, especially because HBV is a non-cytopathogenic virus. No significant statistical association was found between positivity for HBsAg/HBcAg by IHC and antiviral treatment. Conclusions: Determination of the expression patterns of HBV antigens in liver biopsies obtained from chronic hepatitis B Omani patients and the association between these expression patterns with other clinical histopathological parameters and anti-viral therapy, will contribute greatly to a better understanding of the pathogenesis of HBV in this unique cohort group of infected individuals.
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Biomedical and Pharmacology Journal
Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology
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1.20
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0.00%
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189
期刊介绍: Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.
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