{"title":"菟丝子及其成分多方面抗癌活性的研究进展:过去、现在和未来","authors":"R. Banerjee, Sudeepa Ghosh, A. Chowdhury","doi":"10.55766/sujst-2023-02-e02062","DOIUrl":null,"url":null,"abstract":"Ocimum sanctum Linn (OS), is the medicinal herb belonging to the Lamiaceae family, well-known as the ‘Holi Basil’ or ‘Tulsi”. It has been a part of ayurveda and Indian culture for its tremendous ethnomedicinal significance as it is employed to cure common cough and cold along with bronchitis, skin diseases, insect bite etc. The leaves of OS in particular are widely used for the treatment of cancer. Approximately 15 different types of biologically active chemicals have been extracted, purified and identified from this medicinal herb. The anticancer properties of the crude and purified products from OS have been studied extensively over decades. They showed tumor suppressive, radioprotective, chemo-preventive, anti-metastatic, anti-angiogenic and apoptotic effect on various types of cancer. This review summarizes the anticancer effect and mechanism of the purified products and extract obtained from OS on various cancers like breast, colon, lung, liver etc. The summarized report would help to fine-tune our understanding on the anti-cancer properties of OS that might open up new horizon in developing natural product-based cost- efficient cancer drug.","PeriodicalId":43478,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"32 1","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"REVIEW ON MULTIFACETED ANTICANCER ACTIVITY OF OCIMUM SANCTUM AND ITS CONSTITUENTS: PAST, PRESENT AND FUTURE\",\"authors\":\"R. Banerjee, Sudeepa Ghosh, A. Chowdhury\",\"doi\":\"10.55766/sujst-2023-02-e02062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ocimum sanctum Linn (OS), is the medicinal herb belonging to the Lamiaceae family, well-known as the ‘Holi Basil’ or ‘Tulsi”. It has been a part of ayurveda and Indian culture for its tremendous ethnomedicinal significance as it is employed to cure common cough and cold along with bronchitis, skin diseases, insect bite etc. The leaves of OS in particular are widely used for the treatment of cancer. Approximately 15 different types of biologically active chemicals have been extracted, purified and identified from this medicinal herb. The anticancer properties of the crude and purified products from OS have been studied extensively over decades. They showed tumor suppressive, radioprotective, chemo-preventive, anti-metastatic, anti-angiogenic and apoptotic effect on various types of cancer. This review summarizes the anticancer effect and mechanism of the purified products and extract obtained from OS on various cancers like breast, colon, lung, liver etc. The summarized report would help to fine-tune our understanding on the anti-cancer properties of OS that might open up new horizon in developing natural product-based cost- efficient cancer drug.\",\"PeriodicalId\":43478,\"journal\":{\"name\":\"Suranaree Journal of Science and Technology\",\"volume\":\"32 1\",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Suranaree Journal of Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55766/sujst-2023-02-e02062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Suranaree Journal of Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55766/sujst-2023-02-e02062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
Ocimum sanctum Linn (OS)，是一种属于Lamiaceae家族的草药，被称为“Holi罗勒”或“Tulsi”。它已经成为阿育吠陀和印度文化的一部分，因为它具有巨大的民族医学意义，因为它被用来治疗常见的咳嗽和感冒，以及支气管炎、皮肤病、昆虫叮咬等。尤其是OS的叶子被广泛用于治疗癌症。大约有15种不同类型的生物活性化学物质已经从这种草药中提取、纯化和鉴定。几十年来，人们对黄芪粗提取物和纯化产物的抗癌特性进行了广泛的研究。对不同类型的肿瘤具有抑制、放射防护、化学预防、抗转移、抗血管生成和细胞凋亡的作用。本文就其纯化产物及提取物对乳腺癌、结肠癌、肺癌、肝癌等多种肿瘤的抗癌作用及其机制进行综述。总结的报告将有助于调整我们对OS抗癌特性的理解，这可能为开发基于天然产物的低成本抗癌药物开辟新的视野。
REVIEW ON MULTIFACETED ANTICANCER ACTIVITY OF OCIMUM SANCTUM AND ITS CONSTITUENTS: PAST, PRESENT AND FUTURE
Ocimum sanctum Linn (OS), is the medicinal herb belonging to the Lamiaceae family, well-known as the ‘Holi Basil’ or ‘Tulsi”. It has been a part of ayurveda and Indian culture for its tremendous ethnomedicinal significance as it is employed to cure common cough and cold along with bronchitis, skin diseases, insect bite etc. The leaves of OS in particular are widely used for the treatment of cancer. Approximately 15 different types of biologically active chemicals have been extracted, purified and identified from this medicinal herb. The anticancer properties of the crude and purified products from OS have been studied extensively over decades. They showed tumor suppressive, radioprotective, chemo-preventive, anti-metastatic, anti-angiogenic and apoptotic effect on various types of cancer. This review summarizes the anticancer effect and mechanism of the purified products and extract obtained from OS on various cancers like breast, colon, lung, liver etc. The summarized report would help to fine-tune our understanding on the anti-cancer properties of OS that might open up new horizon in developing natural product-based cost- efficient cancer drug.
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