Optimal design of automatic control system for the fed-batch production of 1,3-propanediol with pH logic control

In this work, the fed-batch fermentation of glycerol by Klebsiella pneumoniae with pH logic control is discussed. We propose a hybrid system constrained optimal control problem with glycerol feeding instants as control variables to maximize the concentration of the objective product at the terminal time. Correspondingly, we explore an automatic control system to implement the optimal control strategy, in which the designs of control diagram, PLC control and supervisory computer control system are involved. This work achieves a goal of applying numerical optimal control analysis to the design of control system in glycerol fed-batch fermentation.