臭椿茎皮部位和cantin -6- 1的抗肿瘤活性

A. Said, K. Rashed, H. Tokuda, A. Huefner
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引用次数: 2

摘要

该生物碱化合物是从埃及产臭椿茎皮70%甲醇提取液的氯仿部分分离得到的。对黄连茎皮连续提取液和分离得到的化合物canthin-6- 1进行化学预防活性筛选。与石油醚、乙醚和甲醇70%提取物相比,氯仿提取物在体内短期抗肿瘤启动子试验和eb病毒早期抗原诱导试验中表现出较强的抑制作用。分离得到的化合物canthin-6- 1在实验过程中也表现出较强的活性。进一步研究了这些有用材料在小鼠两阶段皮肤癌变试验中的抑制作用。氯仿提取物及其活性成分canin -6- 1在促进期平均每只小鼠乳头瘤数和百分比均有降低作用。在体内致癌试验中发现这些材料表现出良好的抗肿瘤促进活性。
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Antitumor activity of Ailanthus excelsa (Roxb) stem bark fractions and Canthin-6-one
The alkaloidal compound was isolated from chloroform fraction of methanol 70% extract of Ailanthus excelsa stem bark of Egyptian origin. Successive extracts of A. excelsa stem bark and the isolated compound canthin-6-one were screened for chemopreventive activity. The chloroform extract showed strong inhibitory effect on short term in vivo assay for antitumor promotors, Epstein-Barr virus early antigen induction assay, compared with other fractions petroleum ether, diethyl ether and methanol 70% extracts. The isolated compound canthin-6-one also showed strong activity in the course of this assay. Further, these useful materials were investigated for the inhibitory effects in two-stage mouse skin carcinogensis test. Chloroform extract and its active canthin-6-one decrease actually the average number of papillomas per mouse and percentage papillomas in the promoting stage. These materials were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogensis test.
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