{"title":"铂类药物偶联物的大分子设计","authors":"N. Koseva","doi":"10.4172/2167-065X.S2-006","DOIUrl":null,"url":null,"abstract":"Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.","PeriodicalId":10410,"journal":{"name":"Clinical Pharmacology & Biopharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Macromolecular Design of Platinum Drug Conjugates\",\"authors\":\"N. Koseva\",\"doi\":\"10.4172/2167-065X.S2-006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.\",\"PeriodicalId\":10410,\"journal\":{\"name\":\"Clinical Pharmacology & Biopharmaceutics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Pharmacology & Biopharmaceutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2167-065X.S2-006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Pharmacology & Biopharmaceutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2167-065X.S2-006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.
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