COVID-19诱导继发性噬血细胞性淋巴组织细胞增多症:一个病例系列

Omelkhir I. Elbanoni, H. A. Elhashmi, Mariam M. Madani, Huda A. Elabbud, Shirin Alougly, Nourz A. Elghariani
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引用次数: 0

摘要

噬血细胞性淋巴组织细胞增多症(HLH)是一种致死性和快速进展的高炎症状态,可导致暴发性多器官功能衰竭的发展。HLH分为原发性或家族性HLH (FHL)和继发性HLH (sHLH)。它可以由多种影响免疫系统的因素触发,感染是常见的触发因素。最近,冠状病毒病(COVID-19)在全球蔓延,并被宣布为大流行。儿童感染COVID-19可诱发称为多系统炎症综合征(MIS-C)的严重高炎症综合征。临床MIS-C患者表现出类似川崎病或中毒性休克综合征的特征,临床和实验室表现也可能类似于继发性噬血细胞性淋巴组织细胞增多症或巨噬细胞激活综合征(MAS)。报告的COVID-19儿童HLH综合征在2020-2021年期间有所增加。在这个病例系列中,我们报告了两名被诊断为COVID-19感染后sHLH的儿科患者,并简要回顾了类似儿科患者的文献。
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COVID-19 Induced Secondary Hemophagocytic Lymphohsitocytosis: A Case Series
Hemophagocytic lymphohistiocytosis (HLH) is a lethal and rapidly progressive hyper-inflammatory state that lead to development of fulminant multi-organ failure. HLH is divided into primary or familial HLH (FHL) and secondary HLH (sHLH). It can be triggered by a variety of agent that affect the immune system, infection is a common triggering agent. Recently, Coronavirus disease (COVID-19) has spread all over the world and was declared a pandemic. COVID-19 infection in children can induce serious hyper-inflammatory syndrome termed multisystem inflammatory syndrome (MIS-C). Clinically MIS-C patients present with features that resemble Kawasaki’s disease or toxic shock syndrome and the clinical and laboratory manifestations may also similar to that of secondary hemophagocytic lymphohistiocytosis, or macrophage activation syndrome (MAS). The reported HLH syndrome in children with COVID-19 increased during 2020-2021. In this case series we present two pediatric patient diagnosed as sHLH post- COVID-19 infection with a brief literature review of similar pediatric patients. 
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