(±)谷酸酯的全合成

Natural Product Letters Pub Date : 2001-12-01 DOI:10.1080/10575630108041309

J. Krauss

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引用次数: 9

摘要

摘要以己-5-烯醇为起始原料，经8步合成了天然聚酮(±)-tanikolide(1)，主要步骤为Sharpless二羟基化反应和烷基卤化物与酮的Grignard反应。内酯化是在伯醇官能团氧化为羧基时自发发生的。

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Total Synthesis of (±) Tanikolide

Abstract The natural polyketide (±)-tanikolide (1) was prepared in eight steps starting from hex-5-enol, Key steps in this synthesis are a Sharpless dihydroxylation and a Grignard reaction between an alkyl halogenide and a ketone. The lactonization occurred spontaneously during the oxidation of the primary alcohol function to the carboxy group.

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Natural Product Letters

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