二乙醇胺致小鼠肝脏脂肪变性及姜黄素的改善作用

IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Acta Chemica Iasi Pub Date : 2019-06-01 DOI:10.2478/achi-2019-0009
Hetal Doctor, Sanman Samova, R. Verma
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引用次数: 0

摘要

个人护理产品中化学品的广泛使用导致了许多健康问题。二乙醇胺就是这样一种有害化学物质,它含有两个高官能团醇和胺,需要进行毒理学评估和缓解。采用瑞士白化病小鼠,分为不同的对照组和治疗组。不同剂量的DEA(110、165和330 mg/kg体重/天)口服30天。在治疗结束时进行生化和组织病理学评估。结果显示,dea治疗组体重减轻,肝脏绝对重量和相对重量显著增加。生化分析显示,DEA处理进一步促进大鼠脂质和胆固醇含量呈剂量依赖性显著升高(P<0.05),并导致蛋白质和糖原含量降低。组织病理学检查证实了由于肝组织内脂质积累而形成的空泡。姜黄素(10、20和30 mg/kg体重/天)和高剂量DEA (330 mg/kg体重/天)可改善血脂、胆固醇、蛋白质和糖原含量。它还有助于保持肝脏的正常组织结构。所有组的观察和结果表明,DEA治疗导致肝脂肪变性,姜黄素治疗减弱了DEA的作用,这是由于其潜在的抗氧化特性。
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Diethanolamine-Induced Hepatic Steatosis in Mice and Its Amelioration by Curcumin
Abstract Extensive use of chemicals in personal care products has led to many health issues. Diethanolamine is one of such harmful chemicals containing two highly functional groups alcohol and amine that requires toxicological evaluation and its mitigation. Swiss strain albino mice were used and divided into different control and treated groups. Different doses of DEA (110, 165 and 330 mg/kg body weight/day) were orally administered for 30 days. Biochemical and histopathological assessments were performed at the end of the treatment. Results collectively revealed body weight loss as well as significant increase in absolute and relative liver weight in DEA-treated groups. Biochemical analysis revealed that DEA treatment further promotes significant (P<0.05), dose-dependent increase in lipid and cholesterol contents and also cause decrease in protein and glycogen content. Histopathological assessment confirms vacuole formation due to accumulation of lipid within the liver tissue. Administration of curcumin (10, 20 and 30 mg/kg body weight/day) along with high dose of DEA (330 mg/kg body weight/day) showed improved values of lipid, cholesterol, protein and glycogen contents. It also helped retaining normal histological structure of liver. Observations in all groups and results indicate DEA-treatment causes hepatic steatosis and treatment of curcumin attenuated effect of DEA that is due to its potential antioxidant properties.
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Acta Chemica Iasi
Acta Chemica Iasi CHEMISTRY, MULTIDISCIPLINARY-
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