氟西汀作为药物生物降解研究中活性污泥活性监测参考化合物的生物降解特性

Y. Martín-Biosca, L. Escuder-Gilabert, M. Pérez-Baeza, Maria Jos Medina-Hernndez
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引用次数: 2

摘要

生物可降解性试验是设计用来测试化学物质作为混合接种体中唯一的碳源。经合组织现成的生物降解性试验(RBTs)被用作筛选方法,以提供关于化学品在大多数环境条件下的潜在持久性的信息[b]。这一危险参数取决于化合物的化学结构以及降解过程发生的条件。药物生物降解性研究是当前环境研究的重点[5-10]。这是由于它们的广泛使用和持续释放到环境中以及随后的影响。
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Biodegradability Features of Fluoxetine as a Reference Compound for Monitoring the Activity of Activated Sludges in Drug Biodegradation Studies
Biodegradability assays are designed to test a chemical substance as the sole carbon source in a mixed inoculum [3]. The OECD ready biodegradability tests (RBTs) are used as screening methods to provide information about of the potential persistence of chemicals under most environmental conditions [4]. This risk parameter depends on the chemical structure of the compound as well as on the conditions under which the degradation process takes place. Drugs biodegradability studies are currently a priority in environmental studies [5-10]. This is due to their extensive use with a continuous release into the environment and the subsequent impact.
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