药物的液相色谱(HPLC)分析实验设计:分析、应用、意义和未来展望

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2017-07-27 DOI:10.1515/revac-2016-0025
S. B. Ganorkar, A. Shirkhedkar
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引用次数: 29

摘要

摘要:本文介绍了在高效液相色谱(HPLC)的高度关注中引入液相色谱(LC)的基本简史、关键分析、精确应用和值得注意的实验设计的意义,并扩大了其对药物分析相关技术的印象。作为这方面应用最广泛的统计方法,它的使用始于1970年,并在1981年费舍尔的宝贵投入后得到加强。一个接一个的统计方法的持续使用导致了药物分析人员的有效关注。因此,为了对累积趋势所留下的痕迹进行微调,本文回顾了统计设计在HPLC分析中的应用,并努力认识其相对影响和相应的未来前景。对精确方法的应用进行了重新评估,考虑到最近的监管观点所确立的需要,以及对突出的历史进步和具体目的的狂热和随之而来的立场。我们还努力对LC和相关分析中的不同设计类型和简洁的应用程序进行了任意分类。
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Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects
Abstract This review presents the essential brief annals, crucial analytics, precise applications and noteworthy implications of design of experiments which enrouted to liquid chromatography (LC) in the midst of utmost focus on high-performance liquid-chromatography (HPLC) and broadened its impressions on allied techniques in pharmaceutical analysis. Being most widely applied statistical methodologies for such purpose, its use was started in 1970 and heightened after Fischer’s precious input in 1981. The persistent use of statistical approaches one after another led to the efficient attention of pharmaceutical analysts. Hence, in order to fine-tune the trail impressed by the cumulative trends, the use of statistical designs in HPLC analysis has been reviewed and efforts were made to recognize its relative impact and corresponding future prospects. Applications of precise methodologies have been reassessed with respect to the need established by recent regulatory perspectives with a fanatical and the consequent stance on prominent historical advancements and concrete purposes. An effort was also made to state an arbitrary classification of diverse design types and succinct line of application in LC and associated analyses.
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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