单独用药与认知行为疗法治疗儿童多动症的比较研究

Z. Alina, Abida Niazi, Ambreen Mehmood, H. Ijaz, Abida Hussain, Sabika Zaheer, H. Nasar, H. Shahid, F. Sundus, S. Nawaz, R. Zaheer
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摘要

这项研究很重要,因为长期使用兴奋剂治疗多动症的负面影响,因为它们表现出负面的副作用。长期使用安非他命兴奋剂对神经有毒性,因此必须在治疗ADHD症状时减少剂量,同时产生最大的效果。本文对2000-2015年间的专业文献进行了叙述性回顾。为探索兴奋剂辅助治疗的疗效而进行的试验显示了各种结果。镁和维生素B6的联合补充对多动症,特别是多动症,攻击性和注意力不集中的显著改善产生了积极的效果。与不加锌的高剂量安非他明相比,加锌30毫克或更多的安非他明有助于将安非他明的用量降低至少20%,同时产生相同的结果。锌+哌甲酯联用对降低ADHD症状有积极效果;然而,由于需要对不同剂量的锌进行更多的试验,结果并不是决定性的。根据临床研究,膳食补充剂对治疗ADHD症状是有用的。临床试验表明,锌和镁+B6在减轻多动症症状方面产生了积极的结果。在目前的ADHD治疗中,持续使用兴奋剂会导致耐受性,并随着持续使用而增加;因此,兴奋剂的剂量也需要增加,以达到疗效。添加辅助性膳食补充剂已经证明可以降低兴奋剂的剂量。然而,需要进一步的研究来考虑生物利用度、其他剂量的功效、饮食和任何其他可能阻碍膳食补充剂内部功能的因素。
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Comparative Study of Treatments of Children with ADHD with Medication Alone Vs Medication with Cognitive Behavioral Therapy
This study is important due to the long terms negative effects of using stimulants for ADHD therapy as they manifest negative side effects. The amphetamine stimulants are neurotoxic with long-terms use and it’s imperative to use it in lower dosages while at the same time yielding the maximum affects to treat ADHD symptoms. This narrative review is conducted to explore the professional literature between 2000-2015. The trials conducted to explore the efficacy of adjunctive therapy with stimulants demonstrated various results. The supplementation of combined magnesium and vitamin B6 yielded positive results with significant improvement in ADHD, specifically in hyperactivity, aggression, and low attention span. Zinc supplementation, with 30 mg or more, with amphetamine aided in lowering the dosage of amphetamine use by at least 20% while yielding the same results compared to higher amphetamine use without zinc. Zinc + methylphenidate combination yielded positive results to lower ADHD symptoms; however the results are not conclusive due to more trials are needed in different dosages of zinc. Based on the clinical studies, dietary supplements are useful in treating ADHD symptoms. Clinical trials with zinc and magnesium+B6 have shown to yield positive results in lowering the ADHD symptoms. With current ADHD therapy, continued stimulant use leads to tolerance and increases with continued use; hence the stimulant dosage also needs to be increased to reach efficacy. Adding adjunctive dietary supplements have demonstrated that the stimulant dosages can be lowered. However, further study is needed to factor in bioavailability, efficacy of other dosages, diet, and any other factors that could hinder the function of the dietary supplements internally.
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