小麦草汁对环磷酰胺诱导的雄性Wistar白化大鼠生育能力变化的影响

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-06-30 DOI:10.13005/bpj/2682

Akshatha P Kamath, N. Patil, Amrita Parida, Karthik Rao, Nadeem Khan G, S. Gurung, Afreen Begum H Itagi, M. V, Heraa Islam, Mohsin Nazeer, S. Hegde, N. Anand

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引用次数: 0

摘要

本研究考察了环磷酰胺对小麦草汁精子参数、生化参数、组织病理学及保护作用的生殖毒性。成年Wistar白化大鼠共6组。每组6只。末次给药24h后处死大鼠颈椎脱位，测定睾丸组织中精子数量、活力、血浆丙二醛(MDA)水平、过氧化氢酶(CAT)水平、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)活性等精子参数，并观察睾丸组织病理变化。环磷酰胺使血浆MDA水平升高，SOD、GSH和过氧化氢酶活性降低。这些值具有统计学意义。然而，小麦草汁与环磷酰胺一起处理明显改善了环磷酰胺诱导的氧化应激，并使精子特征和睾丸组织病理学正常化。综上所述，环磷酰胺引起生育能力改变，导致男性不育，而小麦草汁对扭转睾丸损伤和男性不育具有保护作用。

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Effect of Wheatgrass Juice on Fertility Changes Induced by Cyclophosphamide in Male Wistar Albino Rats

In the present study, reproductive toxicity caused by cyclophosphamide on sperm parameters, biochemical parameters, histopathology and protective effect of wheatgrass juice was examined. There were total 6 groups of adult Wistar albino rats. Each group had 6 rats. After 24hrs of the last treatment, rats were sacrificed by cervical dislocation and sperm parameters like sperm count and motility, plasma malonaldehyde (MDA) levels, catalase (CAT) levels, superoxide dismutase (SOD) and glutathione (GSH) activities in testicular tissue, and testicular histopathological changes in the testicular tissue were examined. Administration of cyclophosphamide showed an increase in plasma MDA level and decrease in SOD, GSH and Catalase activity. These values were statistically significant. However, wheatgrass juice treatment along with cyclophosphamide markedly showed improvement in reducing Cyclophosphamide-induced oxidative stress, and normalized sperm characteristics and testicular histopathology. Thus, in conclusion, cyclophosphamide causes fertility changes which leads to male infertility, whereas wheatgrass juice has a protective effect on reversing the testicular damage and male infertility.

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

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