糖化蛋白的富集和分析

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2022-01-01 DOI:10.1515/revac-2022-0036
S. Cho, Van-An Duong, Jeong-Hun Mok, MinJoong Joo, Jong-Moon Park, Hookeun Lee
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引用次数: 7

摘要

糖基化是赖氨酸、精氨酸和蛋白质n端在翻译后的自发修饰。蛋白质糖化与人类疾病的发病机制密切相关,包括糖尿病、阿尔茨海默病、肾脏疾病和癌症。晚期糖基化终产物(AGEs)的水平与许多疾病的进展呈正相关。然而,糖基化相关产物的分析仍然具有挑战性,如活性羰基物质、希夫碱、Amadori化合物和AGEs,因为它们具有高度的异质性。许多分析方法,如荧光检测、免疫测定和液相色谱-串联质谱法,都试图将糖基化产物与疾病联系起来。由于糖化蛋白在血浆中的丰度较低,一些富集方法已被用于增加检测糖化蛋白的概率。本文综述了目前用于鉴定糖基化作为探索性研究中的疾病生物标志物的富集和分析方法。
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Enrichment and analysis of glycated proteins
Abstract Glycation is a spontaneous post-translational modification of lysine, arginine, and the N-terminus of proteins. Protein glycation is closely related to the pathogenesis of human diseases, including diabetes, Alzheimer’s disease, renal disease, and cancer. The levels of advanced glycation end products (AGEs) are positively correlated with the progression of many diseases. However, it remains challenging to analyze glycation-related products, such as reactive carbonyl species, Schiff bases, Amadori compounds, and AGEs, because of their high heterogeneity. Many analysis methods, such as fluorescence detection, immunoassays, and liquid chromatography-tandem mass spectrometry, have attempted to correlate glycation products with diseases. Some enrichment methods have been used to increase the probability of detection of glycated proteins due to their low abundance in blood plasma. This review summarizes the enrichment and analysis methods that are currently used to identify glycation as a disease biomarker in exploratory studies.
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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