{"title":"吡格列酮载牛血清白蛋白纳米颗粒与胡椒碱的制备及评价","authors":"Bindu Madhavi Boddupalli , Prasad Masana , Ravinder Nath Anisetti , Siri Vennela Kallem , Bhavana Madipoju","doi":"10.1016/j.dit.2013.05.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine.</p></div><div><h3>Methods</h3><p>Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized.</p></div><div><h3>Results</h3><p>BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution.</p></div><div><h3>Conclusion</h3><p>The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.</p></div>","PeriodicalId":11284,"journal":{"name":"Drug Invention Today","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dit.2013.05.011","citationCount":"11","resultStr":"{\"title\":\"Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine\",\"authors\":\"Bindu Madhavi Boddupalli , Prasad Masana , Ravinder Nath Anisetti , Siri Vennela Kallem , Bhavana Madipoju\",\"doi\":\"10.1016/j.dit.2013.05.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine.</p></div><div><h3>Methods</h3><p>Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized.</p></div><div><h3>Results</h3><p>BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution.</p></div><div><h3>Conclusion</h3><p>The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.</p></div>\",\"PeriodicalId\":11284,\"journal\":{\"name\":\"Drug Invention Today\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.dit.2013.05.011\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Invention Today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0975761913000574\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Invention Today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0975761913000574","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine
Aim
To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine.
Methods
Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized.
Results
BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution.
Conclusion
The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
