未经治疗的非典型左股骨干骨折并发症1例

Dany k. Aouad, Nagham Azar, M. Daher, N. Dib, George S El Rassi
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摘要

背景:双膦酸盐治疗用于治疗骨质疏松症,降低椎体和髋部骨折的风险。这些药物通过诱导抑制骨吸收和增加骨矿物质密度来抑制破骨细胞的活性。研究表明,长期使用双膦酸盐与非典型股骨骨折的发生率增高有关。病例报告:这是一个81岁女性的病例报告,双膦酸盐治疗12年,慢性左大腿疼痛两年半,发展为不完全非典型左股骨骨折。本病例的特殊之处在于,骨折被忽视,三个月后发展为完全移位的螺旋骨折,需要手术固定。结论:双膦酸盐治疗预防骨质疏松性骨折的益处大于非典型骨折发生的风险。骨科医生和初级保健医生在鉴别诊断有前驱症状和长期接受双膦酸盐治疗的患者时,必须保持非典型骨折
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Untreated Atypical Left Femoral Shaft Fracture: A Case Report of Its Complication
Background: Bisphosphonate therapy is used to manage osteoporosis and decrease the risk of vertebral and hip fractures. These drugs act by suppressing osteoclast activity by inducing the inhibition of bone resorption and increasing bone mineral density. It has been shown that long-term use of bisphosphonate is correlated to a higher incidence of atypical femoral fractures. Case report: This is a case report of an 81-year-old female, on bisphosphonate therapy for 12 years and with chronic left thigh pain for two and a half years who developed an incomplete atypical left femur fracture. What’s special about this case is that the fracture was ignored and then progressed after three months into a complete displaced spiral fracture that required surgical fixation. Conclusion: The benefits of bisphosphonate treatment in preventing osteoporotic fractures outweigh the risk of the occurrence of these atypical fractures. Orthopedic surgeons as well as primary care physicians must keep atypical fractures in their differential diagnosis in patients presenting with prodromal symptoms and who are on long-term bisphosphonate therapy
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