内侧前额叶皮层、伏隔核和腹侧被盖区在运动和奖赏中的功能关系。

T. Tzschentke, Werner J. Schmidt
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引用次数: 210

摘要

内侧前额叶皮层(mPFC)对伏隔核(NAS)和腹侧被盖区(VTA)的突出投射是存在的,但很难确定这两个投射的明确功能作用。除了一些需要详细讨论的例外情况外,只有少数操纵mPFC的神经化学和行为效应可以通过调用mPFC- nas投射来解释,而大多数效应与mPFC-VTA-NAS或mPFC-桥脚被盖核(PPTg)-VTA-NAS回路的参与是兼容的。对这些环的组织和功能的了解通常与通过刺激、损伤或注射药物到mPFC获得的结果一致,但这些发现与mPFC- nas投射的功能组织在很大程度上不一致。这篇综述简要地总结了关于mPFC功能相互作用的一些最重要的方面。NAS, VTA和相关区域,并着重于中脑皮层和伏隔皮层多巴胺能投射之间的功能差异,以及脑皮质和伏隔皮质谷氨酸能投射之间的功能差异。
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Functional relationship among medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in locomotion and reward.
Prominent projections of the medial prefrontal cortex (mPFC) to the nucleus accumbens (NAS) and the ventral tegmental area (VTA) exist, but it has been difficult to assign a clear functional role to either of these projections. With some exceptions to be discussed in some detail, only a few neurochemical and behavioral effects of manipulating the mPFC can be explained by invoking the mPFC-NAS projection, while most effects are compatible with an involvement of the mPFC-VTA-NAS or mPFC-pedunculopontine tegmental nucleus (PPTg)-VTA-NAS circuits. What is known about the organization and function of these loops is generally consistent with the results obtained by stimulating or lesioning or injecting drugs into the mPFC, yet these findings are largely inconsistent with the functional organization of the mPFC-NAS projection. This review briefly summarizes some of the most important aspects of what is known about the functional interactions of the mPFC. NAS, VTA, and associated areas, and focuses on functional differences between the mesocortical and the mesoaccumbal dopaminergic projections, and between the corticomesencephalic and the corticoaccumbal glutamatergic projections.
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