S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar
{"title":"ACTRIIA-Fc (sotaterept)在临床前模型中通过平衡TGF-b/BMP信号逆转肺血管重构以减轻肺动脉高压(PAH)","authors":"S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","DOIUrl":null,"url":null,"abstract":"Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"145 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model\",\"authors\":\"S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar\",\"doi\":\"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure\",\"PeriodicalId\":9568,\"journal\":{\"name\":\"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION\",\"volume\":\"145 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model
Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure