Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390
B. Holzgraefe, Håkan Kalzén, A. Larsson
{"title":"Does Veno-Venous Extracoporeal Membrane Oxygenation Reduce Pulmonary Arterial Pressure at Alveolar Hypoxia? A Porcine Experimental Study","authors":"B. Holzgraefe, Håkan Kalzén, A. Larsson","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4390","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77501834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395
S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar
Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure
{"title":"ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model","authors":"S. Joshi, June Liu, R. Pearsall, Gang Li, Ravindra Kumar","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4395","url":null,"abstract":"Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves pulmonary hemodynamics, and improves RV function by reducing Smad2/3 overactivation and rebalancing activin/BMP signaling in pulmonary arteries and RV. These changes could potentially translate to distinct clinical benefit over currently available therapies for PAH. Right Ventricular Systolic Pressure","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84781384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401
L. Yung, P. Yang, T. Dinter, G. Bocobo, Z. Augur, A. Waxman, D. Man, P. Yu
{"title":"Cyclic Car Peptide Targets Pulmonary Vascular Endothelium and Enhances the Efficacy of Prostacyclin in Experimental Pulmonary Hypertension","authors":"L. Yung, P. Yang, T. Dinter, G. Bocobo, Z. Augur, A. Waxman, D. Man, P. Yu","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4401","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87511794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412
Z. Dai, M. Zhu, Y. Peng, N. Machireddy, C. Evans, R. Machado, X. Zhang, Y. Zhao
{"title":"Targeting HIF-2a for the Treatment of Pulmonary Arterial Hypertension","authors":"Z. Dai, M. Zhu, Y. Peng, N. Machireddy, C. Evans, R. Machado, X. Zhang, Y. Zhao","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4412","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87755691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410
S. Abid, E. Marcos, A. Parpaleix, V. Amsellem, M. Breau, Amal Houssaini, Nora Vienney, P. Validire, M. LeFevre, G. Derumeaux, Steve Evans, C. Hubeau, M. Delcroix, R. Quarck, S. Adnot, L. Lipskaia
{"title":"CCR2- and CCR5-Mediated Crosstalk Between Macrophages and Pulmonary-Artery Smooth Muscle Cells Drives Pulmonary Hypertension","authors":"S. Abid, E. Marcos, A. Parpaleix, V. Amsellem, M. Breau, Amal Houssaini, Nora Vienney, P. Validire, M. LeFevre, G. Derumeaux, Steve Evans, C. Hubeau, M. Delcroix, R. Quarck, S. Adnot, L. Lipskaia","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4410","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83114334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393
H. T. Dương, D. Harrison, M. Krause, Ru-Ting Huang, Yun Fang
{"title":"Locus 7q36.1 Harbors a Flow-Sensitive Endothelial Enhancer","authors":"H. T. Dương, D. Harrison, M. Krause, Ru-Ting Huang, Yun Fang","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4393","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"42 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82858693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402
P. Belvitch, H. Wang, Weiguo Chen, L. Meliton, J. G. Garcia, J. Jacobson, S. Dudek
{"title":"Real-Time Characterization of Inflammatory Lung Injury","authors":"P. Belvitch, H. Wang, Weiguo Chen, L. Meliton, J. G. Garcia, J. Jacobson, S. Dudek","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4402","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75454469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407
K. Chaudhary, Y. Deng, Anli Yang, K. Rowe, D. Stewart
{"title":"Female Sex Hormones Can Prevent but Not Reverse Established Pulmonary Arterial Hypertension in the SU5416/Chronic Hypoxia Model","authors":"K. Chaudhary, Y. Deng, Anli Yang, K. Rowe, D. Stewart","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4407","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"175 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85419873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408
Abinaya Nathan, J. Uribe, A. Chakraborty, K. Yuan, E. Shamskhou, K. Suresh, L. Shimoda, V. D. Perez
{"title":"Dysregulated Wnt/Ca2+ Signaling Is Associated with Pericyte Hypercontractility and Proliferation in PAH","authors":"Abinaya Nathan, J. Uribe, A. Chakraborty, K. Yuan, E. Shamskhou, K. Suresh, L. Shimoda, V. D. Perez","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4408","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83487864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413
Victor Tseng, J. Klienhenz, T. Murphy, E. Grayck, C. Hart
{"title":"Targeting Pathologic Hyaluronan Synthesis in Pulmonary Hypertension","authors":"Victor Tseng, J. Klienhenz, T. Murphy, E. Grayck, C. Hart","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4413","url":null,"abstract":"","PeriodicalId":9568,"journal":{"name":"C26. LET IT BLEED: ENDOTHELIAL INJURY AND ANGIOGENESIS IN PULMONARY HYPERTENSION","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80628886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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