{"title":"HLA-Cw和HLA-DRB1等位基因与复发性口腔炎的显著相关性","authors":"Yasuaki Sakata, Shoichiro Kokabu, Junya Nojima, Norimichi Nakamoto, Yosuke Fukushima, Tsuyoshi Sato, Tetsuya Yoda","doi":"10.1016/j.ajoms.2010.10.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leukocyte antigen (HLA) class 1 and class 2 alleles.</p></div><div><h3>Materials and methods</h3><p>Nucleotide sequence level typing of HLA-A, -B, -Cw, and -DRB1 alleles was performed on Japanese patients with RAS and their families. The subjects that participated in this study consisted of 25 families that had at least one patient suffering from RAS.</p></div><div><h3>Results</h3><p>One HLA-Cw allele, Cw*0303, and three HLA-DRB1 alleles, DRB1*0401, DRB1*0803 and DRB1*1101, showed a significant positive association with RAS. No HLA-A and HLA-B alleles showed significant association with RAS.</p></div><div><h3>Conclusion</h3><p>The present study strongly suggests the significant positive association of HLA alleles with RAS. No HLA-A and HLA-B alleles showed significant association with RAS. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of RAS.</p></div>","PeriodicalId":100128,"journal":{"name":"Asian Journal of Oral and Maxillofacial Surgery","volume":"23 1","pages":"Pages 7-9"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ajoms.2010.10.003","citationCount":"4","resultStr":"{\"title\":\"Significant association of HLA-Cw and HLA-DRB1 alleles with recurrent aphthous stomatitis\",\"authors\":\"Yasuaki Sakata, Shoichiro Kokabu, Junya Nojima, Norimichi Nakamoto, Yosuke Fukushima, Tsuyoshi Sato, Tetsuya Yoda\",\"doi\":\"10.1016/j.ajoms.2010.10.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leukocyte antigen (HLA) class 1 and class 2 alleles.</p></div><div><h3>Materials and methods</h3><p>Nucleotide sequence level typing of HLA-A, -B, -Cw, and -DRB1 alleles was performed on Japanese patients with RAS and their families. The subjects that participated in this study consisted of 25 families that had at least one patient suffering from RAS.</p></div><div><h3>Results</h3><p>One HLA-Cw allele, Cw*0303, and three HLA-DRB1 alleles, DRB1*0401, DRB1*0803 and DRB1*1101, showed a significant positive association with RAS. No HLA-A and HLA-B alleles showed significant association with RAS.</p></div><div><h3>Conclusion</h3><p>The present study strongly suggests the significant positive association of HLA alleles with RAS. No HLA-A and HLA-B alleles showed significant association with RAS. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of RAS.</p></div>\",\"PeriodicalId\":100128,\"journal\":{\"name\":\"Asian Journal of Oral and Maxillofacial Surgery\",\"volume\":\"23 1\",\"pages\":\"Pages 7-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ajoms.2010.10.003\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Oral and Maxillofacial Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0915699210001305\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Oral and Maxillofacial Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0915699210001305","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Significant association of HLA-Cw and HLA-DRB1 alleles with recurrent aphthous stomatitis
Objectives
The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leukocyte antigen (HLA) class 1 and class 2 alleles.
Materials and methods
Nucleotide sequence level typing of HLA-A, -B, -Cw, and -DRB1 alleles was performed on Japanese patients with RAS and their families. The subjects that participated in this study consisted of 25 families that had at least one patient suffering from RAS.
Results
One HLA-Cw allele, Cw*0303, and three HLA-DRB1 alleles, DRB1*0401, DRB1*0803 and DRB1*1101, showed a significant positive association with RAS. No HLA-A and HLA-B alleles showed significant association with RAS.
Conclusion
The present study strongly suggests the significant positive association of HLA alleles with RAS. No HLA-A and HLA-B alleles showed significant association with RAS. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of RAS.
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