化妆品和个人护理产品中的内分泌干扰物质与子宫内膜异位症的风险

Francisco M. Peinado, Luz M. Iribarne-Durán, O. Ocón-Hernández, N. Olea, F. Artacho-Cordón
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引用次数: 2

摘要

在过去几年中,化妆品和个人护理产品(pcp)的种类和消费量大大增加,尽管在生产过程中使用的低剂量化学品和已证实的激素模拟特性的长期不利影响仍然没有得到充分解决。在这些内分泌干扰化学物质(EDCs)中,对羟基苯甲酸酯、二苯甲酮、双酚和邻苯二甲酸酯是这些产品中最广泛发现的。考虑到子宫内膜的雌激素依赖性,人们假设化妆品和pcp中含有的EDCs可能会增加子宫内膜异位症的风险。在本书的这一章中,我们总结了支持这一假说的现有证据,强调了流行病学、体内和体外研究,这些研究解决了对羟基苯甲酸酯、二苯甲酮类、双酚类和邻苯二甲酸酯在这种慢性女性疾病的起源和发展中的潜在影响。
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Endocrine Disrupting Chemicals in Cosmetics and Personal Care Products and Risk of Endometriosis
In the last years, the variety and consumption of cosmetics and personal care products (PCPs) have greatly increased, although the long-term adverse effects to low doses of chemicals used in their production and with proven hormone-mimicking properties have been still poorly addressed. Among these endocrine disrupting chemicals (EDCs), parabens, benzophenones, bisphenols, and phthalates are the most widely found in these products. Given the estrogenic-dependent nature of the endometrium, it has been hypothesized the potential contribution of these EDCs contained in cosmetics and PCPs in the risk of endometriosis. In this book chapter, we have summarized the current evidence supporting this hypothesis, highlighting epidemiological, in vivo, and in vitro studies that have addressed the potential influence of parabens, benzophenones, bisphenols, and phthalates in the origin and progression of this chronic feminine disease.
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