南斯拉夫国民军的疫苗接种:前南斯拉夫军队服役期间获得慢性乙型肝炎病毒感染的重要危险因素

N. Kmet, M. Poljak, M. Rajter, Tanja Selič, Z. Baklan, E. Pal, M. Maticic
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引用次数: 1

摘要

背景:为了防止传染病的传播,一些国家军队实施了强制性疫苗接种计划,前南斯拉夫国民军(YNA)也实行了这种计划。在军队接种疫苗期间,医源性乙型肝炎病毒(HBV)的传播有充分的记录,但据我们所知,在前南斯拉夫没有进行过这样的研究。目的:在目前的研究中,我们确定了斯洛文尼亚患者获得慢性乙型肝炎(CHB)感染的危险因素。本研究的重点是在男性中发现一个具有统计学意义的危险因素,即“在YNA接种疫苗”。方法:回顾性纳入1997年1月至2010年12月在病毒性肝炎诊断国家参考实验室检测HBV表面抗原(HBsAg)阳性的来自斯洛文尼亚所有地区的1229例患者。因此,从医学文献中提取人口学、流行病学、病毒学和临床资料,并进行统计分析。结果:在1729例患者中,有1122例(64.9%)患者获得了有关HBV感染危险因素的数据。在现有数据中,近60%的HBV慢性感染者感染的危险因素未知,其次是“家庭中HBV感染”(19.8%)和“90年代以前输血/血液制品”(8%)。7名男性(0.6%)(平均年龄±SD, 53.7±4.50岁)报告“在YNA接种疫苗”是获得慢性HBV感染的危险因素。“在YNA接种疫苗”是46岁以上男性CHB感染的重要危险因素(P = 0.006)。结论:斯洛文尼亚46岁以上男性感染的一个重要危险因素被确定为“YNA疫苗接种”,这是该地理区域特有的,据我们所知,以前在同行评议的文献中没有描述过。
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Vaccination in the Yugoslav National Army: A Significant Risk Factor for Acquiring Chronic Hepatitis B Virus Infection During Army Service in the Former Yugoslavia
Background: To prevent the spread of infectious diseases, several state armies implemented obligatory vaccination programs also practiced in the former Yugoslav National Army (YNA). Iatrogenic hepatitis B virus (HBV) transmissions during vaccinations in the armies were well documented, but to the best of our knowledge, no such study has been performed in the former Yugoslavia. Objectives: In the present study, we determined risk factors for acquiring chronic hepatitis B (CHB) infection in patients in Slovenia. This study focused on the detection of a statistically significant risk factor in males, namely “vaccination in the YNA”. Methods: One thousand seven hundred and twenty-nine patients from all Slovenian regions who tested positive for HBV surface antigen (HBsAg) at the national referential laboratory for viral hepatitis diagnostics between January 1997 and December 2010 were included retrospectively. Accordingly, demographic, epidemiological, virological, and clinical data were extracted from the medical documentation and were statistically analyzed. Results: For 1,122 (64.9%) out of 1,729 patients, data regarding risk factors for acquiring HBV infection were available. The risk factor for infection of almost 60% of HBV chronically infected individuals with available data, followed by “HBV infection in the family” (19.8%) and “blood/blood products transfusion before the nineties” (8%) was unknown. Seven males (0.6%) (mean age ± SD, 53.7 ± 4.50 years) reported “vaccination in the YNA” as a risk factor for acquiring chronic HBV infection. “Vaccination in the YNA” was a significant risk factor for CHB infection in men over 46 years of age (P = 0.006). Conclusions: A significant risk factor for infection in Slovenian men over 46 years of age was identified as “vaccination in the YNA”, which is specific to this geographic region and, to the best of our knowledge, has not been previously described in the peer-reviewed literature.
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