Nail Involvement in Pemphigus: Brief Report

Background: The objective of our study is to describe the different nail involvement at the beginning of the disease according to the type of pemphigus and according to the severity of the pemphigus. Material and methods: We carried out a prospective study over a 3-year period from 2019 to 2022 that included 21 hospitalized patients out of 80 with polydactyly nail involvement 13 pemphigus vulgaris, 4 pemphigus vegetans, and 3 superficial pemphigus in our dermatology department Centre Hospitalier Universitaire (CHU) Hassan II Fez. Results: Paronychia was the most frequent finding overall, observed in 11 (52.38%) cases, followed by onychomadesis and Beau's lines in 8 cases (38%) and subungual hemorrhage in 6 cases (28.57%). Nail involvement was correlated with the severity of the pemphigus, in particular with severe mucosal involvement (17 patients or 80.9%). Conclusion: Nail involvement is a sign of pemphigus severity and may herald an exacerbation of the underlying disease.