罗望子胶和改性罗望子胶给药研究进展

K. Mali, S. Dhawale, R. Dias, V. Ghorpade
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引用次数: 11

摘要

罗望子多糖是一种新兴的赋形剂,正在研究和应用于各种剂型的制备。罗望子胶(TG)的功能化提高了天然罗望子多糖的降解性、水合性、粘度和溶胀性。由于这些优异的性质,研究人员研究了改性TG在各种药物传递系统中的应用。甘油三酯和改性甘油三酯适用于口腔、鼻腔、眼、结肠和局部给药系统的设计。此外,它们还用于制备基于水凝胶的药物传递系统和诸如纳米颗粒的新型药物传递系统。考虑到以上事实,需要进一步的研究工作来确认TG和改性TG在给药中的药用价值。本文对TG和改性TG的医药应用进行了全面而有价值的讨论。
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Delivery of drugs using tamarind gum and modified tamarind gum: A review
Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.
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