Yasmine F Madi, M. Meselhy, E. A. El-kashoury, Mouchira A. Choucry
{"title":"Morphological and Anatomical Characterization of Cymbopogon citratus (DC.) Stapf Cultivated in Egypt","authors":"Yasmine F Madi, M. Meselhy, E. A. El-kashoury, Mouchira A. Choucry","doi":"10.54634/2090-9101.1032","DOIUrl":"https://doi.org/10.54634/2090-9101.1032","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82804093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hefny, S. Galal, A. Ahmed, M. Mansy, S. Shabayek
{"title":"Microbial Contamination Of Non- Sterile Pharmaceutical Drops Produced In Egypt","authors":"M. Hefny, S. Galal, A. Ahmed, M. Mansy, S. Shabayek","doi":"10.54634/2090-9101.1029","DOIUrl":"https://doi.org/10.54634/2090-9101.1029","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77947285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Walaa S. Nasser, M. Mikhail, M. Issa, Essam Abdel-Sattar
{"title":"Effect of Selected Essential Oils Against Zoonoses and their Epidemiological Survey Among Domestic Rodents in Egypt","authors":"Walaa S. Nasser, M. Mikhail, M. Issa, Essam Abdel-Sattar","doi":"10.54634/2090-9101.1031","DOIUrl":"https://doi.org/10.54634/2090-9101.1031","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82928813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morpho-Anatomical Characters Of The Floral Structures Of Erythrina × Neillii Mabberley And Lorence (Fabaceae) And Their Importance To Species Characterization","authors":"S. K. Gabr, R. O. Bakr, A. El-Fishawy, T. El-Alfy","doi":"10.54634/2090-9101.1030","DOIUrl":"https://doi.org/10.54634/2090-9101.1030","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"43 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90478826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Alaribe, Akolade R. Oladipupo, Anjola T. Adebesin, Omolayomi Kaska, E. Toye
{"title":"Phytochemicals, Acute Toxicity and Genotoxicity of Chewing Sticks from Zanthoxylum zanthoxyloides Root and Distemonanthus benthamianus Stem","authors":"C. Alaribe, Akolade R. Oladipupo, Anjola T. Adebesin, Omolayomi Kaska, E. Toye","doi":"10.54634/2090-9101.1027","DOIUrl":"https://doi.org/10.54634/2090-9101.1027","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73337964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Salah Abdulrahman, Hamido M. Hefny, M. Mansy, A. Mekawey
{"title":"Genetic Diversity Of Cladosporium Species Isolated From Air Of Cairo, Egypt Using Microsatellite Primed Pcr (Mp-pcr) And Universally Primed Pcr (Up-pcr) Techniques","authors":"Mohammed Salah Abdulrahman, Hamido M. Hefny, M. Mansy, A. Mekawey","doi":"10.54634/2090-9101.1028","DOIUrl":"https://doi.org/10.54634/2090-9101.1028","url":null,"abstract":"","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79724666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Metwally, Sarah Ali Shalaby, T. Temraz, M. I. Ahmed
Discovering novel drugs for curing cancer and infectious diseases is the prime interest of several research areas now. Marine sessile invertebrates have produced secondary metabolites, a lot of which are utilized as novel pharmaceutical agents with diverse effects whether anti-cancer or anti-microbial. Ascidians are marine sessile animals (phylum: Chordata, class: Ascidiacea). Various anti-cancer, anti-viral, and anti-bacterial components are obtained from different bioactive compounds belonging to ascidian species and are in different stages of clinical trials. In this study, five ascidian species which are Polyclinum constellatum, Botryllus eilatensis, Didemnum sp., Symplegma rubra, and Styela canopus were collected from two coastal sites in Egypt. These specimens were utilized for preparing extracts using organic and inorganic solutions. Crystal violet assay using human breast cancer cell line was performed for evaluation cytotoxic activity of dried extracts, besides the diffusion agar technique to assess anti-microbial activity using 6-type fungi: Aspergillus fumigatus, Aspergillus flavus, Candida albicans, Syncephalastrum racemosum, Candida tropicalis, and Penicillium expansum, Gram-positive Bacteria: Staphylococcus aureus, Bacillus subtilis, and Streptococcus mutants, and Gram-negative bacteria: Enterobacter cloacae, Escherichia coli, and Proteus vulgaris. Two ascidian species, Didemnum sp. and S. rubra, showed significant cytotoxicity against human breast cancer cell line while other species showed moderate cytotoxicity. All investigated ascidian species have antibacterial compounds toward S. aureus and B. subtilis. The only species exhibited antibacterial activity against the fungus A. fumigatus was Botryllus eilatensis Didemnum sp. has exhibited activity against seven microbes, while S. canopus, Botryllus eilatensis, S. rubra, and P. constellatum have exhibited activities against 4,5,4, & 2 microbes from twelve used microbes, respectively. Therefore, ascidian species are excellent species for further studies to discover new pharmaceutical agents in Egypt.
{"title":"Antimicrobial and Cytotoxic activities of Ascidian Species Collected from Egyptian Coasts","authors":"A. Metwally, Sarah Ali Shalaby, T. Temraz, M. I. Ahmed","doi":"10.54634/2090-9101.1026","DOIUrl":"https://doi.org/10.54634/2090-9101.1026","url":null,"abstract":"Discovering novel drugs for curing cancer and infectious diseases is the prime interest of several research areas now. Marine sessile invertebrates have produced secondary metabolites, a lot of which are utilized as novel pharmaceutical agents with diverse effects whether anti-cancer or anti-microbial. Ascidians are marine sessile animals (phylum: Chordata, class: Ascidiacea). Various anti-cancer, anti-viral, and anti-bacterial components are obtained from different bioactive compounds belonging to ascidian species and are in different stages of clinical trials. In this study, five ascidian species which are Polyclinum constellatum, Botryllus eilatensis, Didemnum sp., Symplegma rubra, and Styela canopus were collected from two coastal sites in Egypt. These specimens were utilized for preparing extracts using organic and inorganic solutions. Crystal violet assay using human breast cancer cell line was performed for evaluation cytotoxic activity of dried extracts, besides the diffusion agar technique to assess anti-microbial activity using 6-type fungi: Aspergillus fumigatus, Aspergillus flavus, Candida albicans, Syncephalastrum racemosum, Candida tropicalis, and Penicillium expansum, Gram-positive Bacteria: Staphylococcus aureus, Bacillus subtilis, and Streptococcus mutants, and Gram-negative bacteria: Enterobacter cloacae, Escherichia coli, and Proteus vulgaris. Two ascidian species, Didemnum sp. and S. rubra, showed significant cytotoxicity against human breast cancer cell line while other species showed moderate cytotoxicity. All investigated ascidian species have antibacterial compounds toward S. aureus and B. subtilis. The only species exhibited antibacterial activity against the fungus A. fumigatus was Botryllus eilatensis Didemnum sp. has exhibited activity against seven microbes, while S. canopus, Botryllus eilatensis, S. rubra, and P. constellatum have exhibited activities against 4,5,4, & 2 microbes from twelve used microbes, respectively. Therefore, ascidian species are excellent species for further studies to discover new pharmaceutical agents in Egypt.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"348 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86795778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferula asafoetida is a plant from Umbelliferae Family, which its gum is traditionally used to treat the gastrointestinal disorders (parasite, bloating, digestion, cancer). According to its traditional applications, the subject of this review was to evaluate the efficacy of F. asafoetida in management of different gastrointestinal disorders in modern medicine. For this purpose, the scientific resources (PubMed, Web of Science, Scopus, Google Scholar, SpringerLink, SciFinder, ACS Publications, and Wiley), traditional books, and thesis were investigated by the word of F. asafoetida, Hing, and gastrointestinal tract and the results were evaluated. There was one clinical trial on the efficacy of F. asafoetida in treatment of functional dyspepsia, and the other pharmacological activities such as anti-parasite, anti-cancer, antidiarrhea and liver protective effects were evaluated in preclinical studies. Although, F. asafoetida can be proposed as a good candidate for treatment of gastrointestinal disorders, but the majority of studies have been limited to the experimental investigations. Therefore, evaluation of its efficacy and safety in well-designed human clinical studies is required to use of this valuable oleo-gum resin.
阿魏是伞形科的一种植物，其树胶传统上用于治疗胃肠道疾病(寄生虫、腹胀、消化、癌症)。根据其传统应用，本文综述了牛油果在现代医学中治疗不同胃肠道疾病的疗效。为此，以F. asafoetida、Hing、胃肠道为检索词，对科学资源(PubMed、Web of Science、Scopus、Google Scholar、SpringerLink、SciFinder、ACS Publications、Wiley)、传统图书、论文进行调查，并对结果进行评价。已有一项临床试验研究了牛油果治疗功能性消化不良的疗效，临床前研究对牛油果抗寄生虫、抗癌、止泻、保肝等药理活性进行了评价。虽然asafoetida可以作为治疗胃肠道疾病的良好候选者，但大多数研究都局限于实验研究。因此，需要在设计良好的人体临床研究中评估其有效性和安全性，以使用这种有价值的油胶树脂。
{"title":"The beneficial effects of Ferula asafoetida oleo-gum resin in gastrointestinal disorders","authors":"M. Mahboubi","doi":"10.54634/2090-9101.1025","DOIUrl":"https://doi.org/10.54634/2090-9101.1025","url":null,"abstract":"Ferula asafoetida is a plant from Umbelliferae Family, which its gum is traditionally used to treat the gastrointestinal disorders (parasite, bloating, digestion, cancer). According to its traditional applications, the subject of this review was to evaluate the efficacy of F. asafoetida in management of different gastrointestinal disorders in modern medicine. For this purpose, the scientific resources (PubMed, Web of Science, Scopus, Google Scholar, SpringerLink, SciFinder, ACS Publications, and Wiley), traditional books, and thesis were investigated by the word of F. asafoetida, Hing, and gastrointestinal tract and the results were evaluated. There was one clinical trial on the efficacy of F. asafoetida in treatment of functional dyspepsia, and the other pharmacological activities such as anti-parasite, anti-cancer, antidiarrhea and liver protective effects were evaluated in preclinical studies. Although, F. asafoetida can be proposed as a good candidate for treatment of gastrointestinal disorders, but the majority of studies have been limited to the experimental investigations. Therefore, evaluation of its efficacy and safety in well-designed human clinical studies is required to use of this valuable oleo-gum resin.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90529705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Falah Hassan Sheri, Hiba Dawood, Jubran K Hassan, Qais A. Aljazaeari
Background: Taurine is sulfur containing semi-essential amino acid that has important roles in many biological processes, but; its effects on glucose homeostasis, weight; growth and bone mineralization were not well defined in human. Objectives: evaluation the effects of oral taurine used for 3 months on bone mineralization biomarker; glycemic control and body weight in type II diabetic patients. Methods: interventional double-blind placebo-controlled study in which 80 patients with type2 diabetes mellitus (age range 45e55) assigned in either control (n 1⁄4 40) or study (n 1⁄4 40) group. The last group received 1000 mg capsule of taurine once a -d for three months. Parameters measured were serum calcium, 25(OH) vitamin D and osteocalcin, NTX-1; HbA1C% and Fasting blood glucose before and after 3 months. Results: Taurine led to significant (p < 0.05) rise in osteocalcin and significant lowering in Body weight and BMI and there were no significant changes in Serum Calcium; NTX-1; Vitamin D; HbA1C% and fasting blood glucose; all as compared with control values. Conclusion: 3 months of oral Taurine used in type II diabetic patients may modulate bone mineralization represented by elevation of osteocalcin; and reduction of body weight, but has no significant effect on glycemic control and did not reduce HbA1C%
{"title":"Study the Effects of Taurine Oral Supplement used for Type 2 Diabetic Patients on Body Weight; Glycemic Control and Some Bone Mineralization Biochemical Markers","authors":"Falah Hassan Sheri, Hiba Dawood, Jubran K Hassan, Qais A. Aljazaeari","doi":"10.54634/2090-9101.1022","DOIUrl":"https://doi.org/10.54634/2090-9101.1022","url":null,"abstract":"Background: Taurine is sulfur containing semi-essential amino acid that has important roles in many biological processes, but; its effects on glucose homeostasis, weight; growth and bone mineralization were not well defined in human. Objectives: evaluation the effects of oral taurine used for 3 months on bone mineralization biomarker; glycemic control and body weight in type II diabetic patients. Methods: interventional double-blind placebo-controlled study in which 80 patients with type2 diabetes mellitus (age range 45e55) assigned in either control (n 1⁄4 40) or study (n 1⁄4 40) group. The last group received 1000 mg capsule of taurine once a -d for three months. Parameters measured were serum calcium, 25(OH) vitamin D and osteocalcin, NTX-1; HbA1C% and Fasting blood glucose before and after 3 months. Results: Taurine led to significant (p < 0.05) rise in osteocalcin and significant lowering in Body weight and BMI and there were no significant changes in Serum Calcium; NTX-1; Vitamin D; HbA1C% and fasting blood glucose; all as compared with control values. Conclusion: 3 months of oral Taurine used in type II diabetic patients may modulate bone mineralization represented by elevation of osteocalcin; and reduction of body weight, but has no significant effect on glycemic control and did not reduce HbA1C%","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88786133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, great advances have been made towards the development of various techniques for novel drug delivery systems. These techniques focus on the rate of drug delivery, duration of action and site of action. One of such technique in fabricating novel drug delivery system is the use of polymers in development of in-situ drug delivery systems. Polymers used as carriers have revolutionized over the years. The formation of a polymer complex with other oppositely charged polymers resulted in the formation of polyelectrolyte complexes, which possess unique physicochemical properties with high biocompatibility. The polyelectrolyte's themselves are characterized as cationic, anionic and non-ionic according to the nature of the functional group present at the polymer chain, type of macromolecules formed and interaction forces existing between the complex formed. Additionally, these natural complexes avoid the use of chemical agents for cross linking of polymeric chains, thereby limiting toxicity. Due to their sustain and convenient way to deliver highly water soluble drugs they could target therapeutically active moiety to the site of action, and for these reasons they have led to various applications in the biomedical sector, in pharmaceutical and nano biotechnology industries. Thereby the use of polymers in in-situ drug delivery offers many benefits because of their sustained and prolonged drug delivery action when compared with other conventional drug delivery systems. The present review focuses on the use of natural Polymers in polyelectrolyte complexes as a drug delivery technology.
{"title":"The Use of Natural Polymers in Formation of Polyelectrolyte Complexation","authors":"N. Lal, Athira R. Nair, N. Verma","doi":"10.54634/2090-9101.1020","DOIUrl":"https://doi.org/10.54634/2090-9101.1020","url":null,"abstract":"In recent years, great advances have been made towards the development of various techniques for novel drug delivery systems. These techniques focus on the rate of drug delivery, duration of action and site of action. One of such technique in fabricating novel drug delivery system is the use of polymers in development of in-situ drug delivery systems. Polymers used as carriers have revolutionized over the years. The formation of a polymer complex with other oppositely charged polymers resulted in the formation of polyelectrolyte complexes, which possess unique physicochemical properties with high biocompatibility. The polyelectrolyte's themselves are characterized as cationic, anionic and non-ionic according to the nature of the functional group present at the polymer chain, type of macromolecules formed and interaction forces existing between the complex formed. Additionally, these natural complexes avoid the use of chemical agents for cross linking of polymeric chains, thereby limiting toxicity. Due to their sustain and convenient way to deliver highly water soluble drugs they could target therapeutically active moiety to the site of action, and for these reasons they have led to various applications in the biomedical sector, in pharmaceutical and nano biotechnology industries. Thereby the use of polymers in in-situ drug delivery offers many benefits because of their sustained and prolonged drug delivery action when compared with other conventional drug delivery systems. The present review focuses on the use of natural Polymers in polyelectrolyte complexes as a drug delivery technology.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89267565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：