类黄酮:保健和医药中的重要资源

S. Rahaman, S. Mondal
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引用次数: 39

摘要

自然界中有许多生物资源对保健至关重要。由于在各种流行病学研究中记录了它们灵活的健康益处,人们对植物来源的类黄酮的研究越来越感兴趣。由于黄酮类化合物与人类膳食成分和健康直接相关,因此需要对其结构和功能关系进行评估。黄酮类化合物的生物利用度、代谢和生物活性取决于其组成、羟基总数和核结构的官能团取代。水果和蔬菜以及茶和酒是人类类黄酮的主要饮食来源。黄酮类化合物具有抗癌、抗氧化、抗高血压、抗胆碱酯酶等多种药理作用,本文对其重要性进行了综述。这些类黄酮在治疗妊娠引起的疾病方面显示出积极的效果。我们也试图讨论一些证明类黄酮治疗COVID-19有效性的研究。它们也被证明在治疗神经退行性疾病方面具有更大的潜力。纳米医学在不久的将来也会发挥更大的作用,因为它可以帮助类黄酮显示有效的靶向药物递送。急性和短期作用,类黄酮改善内皮功能。改善内皮依赖性和一氧化氮依赖性血管舒张已被认为是黄酮类化合物参与内皮和血管功能的可能机制之一。内皮功能的改变也可能导致血压降低。
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Flavonoids: A vital resource in healthcare and medicine
There are many biological resources in nature that are essential in relation to health care. Due to their flexible health benefits documented in various epidemiological studies, there has been increasing interest in research on flavonoids from plant sources. Since flavonoids are directly related to human dietary ingredients and health, structure and function relationships need to be evaluated. Flavonoids bioavailability, metabolism, and biological activity depends on the composition, total number of hydroxyl groups, and functional group substitution regarding their nuclear structure. Fruits and vegetables, together with tea and wine, are the primary dietary sources of flavonoids for humans. This review article primarily focusses on demarcating the importance of flavonoids which shows many pharmacological actions by acting as anti-cancer, anti-oxidant, anti-hypertensive and anti-cholinesterase agents. These flavonoids had shown positive results in treatment of pregnancy induced disorders. We also tried to discuss few studies which proves the efficiency of flavonoids to treat COVID-19. They had also been proved to show greater potential in treatment of Neurodegenerative diseases. Nanomedicine also has a greater part to play in near future as it helps flavonoids show effective targeted drug delivery. acute and short-term action, flavonoids improve endothelial functions. 54-57 Improving endothelial dependent and nitric oxide dependent vasodilation has been suggested as one of the possible mechanisms for involving flavonoids in endothelial and vascular function. The endothelial function change may also lead to lower blood pressure.
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