Influence of Carbopol 971P NF on flow rate and swelling parameters in antifungal tablets

INFLUENCE OF CARBOPOL 971P NF ON FLOW RATE AND SWELLING PARAMETERS IN ANTIFUNGAL TABLETS (Abstract): The purpose of this research laid in develop-ing oromucosal bioadhesive tablets with miconazole nitrate based on hydrophilic bioadhesive polymers, Carbopol 971P NF, capable to form a good adhesion to prolong the duration of the active ingredient action for several hours. The aim is to observe the correlation between the disintegration time, the swelling index and the amount of polymer used in mucoadhesive tablets. Material and methods : The tablets were made using direct compression method, the mucoadhesive tablets differing in the amount of Carbopol 971P NF. The first proposed formula (FI) contains 40 mg polymer and the second one (FII) contains 10 mg polymer. After the formulation and development of mucoadhesive tablets using different grades of polymer, physico-chemical parameters such as surface area, thickness, diameter, friability, hardness, disintegration time and swelling index were determined. Results : Both proposed formulas have an optimal disintegration time of 75 and 98 minutes. The swelling index for FI (18% polymer) is 0.4435 and for FII (4.5% polymer) is 1.0316. Conclusions: Considering that the mucoadhesive tablets imply a swelling index over 1 and a longer disintegration time, the FII formula, with 10 mg carbomer, can be considered optimal.