{"title":"PREDICTIVE SCORES FOR HEPATOCELLULAR CARCINOMA OCCURRENCE AFTER HEPATITIS C VIRUS CURE WITH DIRECT ANTIVIRALS","authors":"Cristina Muzica","doi":"10.22551/msj.2023.03.05","DOIUrl":"https://doi.org/10.22551/msj.2023.03.05","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE IMPACT OF CHRONIC DISEASE ON STUDENTS’ QUALITY OF LIFE","authors":"Ancuta Elena Paduraru","doi":"10.22551/msj.2023.03.02","DOIUrl":"https://doi.org/10.22551/msj.2023.03.02","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
THE FOLLOW-UP OF PATIENTS WITH SURGICAL SOLITARY KIDNEY-THE UN-DERESTIMATED ROLE OF COBORBIDITIES (Abstract): In order to customize the follow-up plan and lower the risks of end-stage renal disease progression (ESRD), we set out to create a monitoring program for patients with surgical solitary kidneys. Additionally, by determining the underlying etiology and comorbidities (such as pre-existing CKD or Diabetes). 91 patients have been found who satisfy the inclusion requirements. Material and methods: There were 51 ladies and 40 guys among them. They ranged in age from 20 to 90. The average age was 60.69 years (SD +/- 15.87). There was no difference in the mean age between the genders (63.22 vs. 58.71, p=0.08). Kidney cancer (50.54%), upper urothelial tract carcinoma (25.27%), pyonephrosis (17.58%), and kidney trauma (6.59%) were the primary pathologies for which surgery was performed. The patients were also arbitrarily separated into three age groups: Group A, 20-40 years old; Group B, 41-60 years old; and Group C, over 60 years old. Results: One month after discharge, C-reactive protein increased (p=0.05), and eGFR decreased significantly (p=0.003). The most common comorbidity (74.72%; n=68) was arterial hypertension. Of these, 51.47% (n=35) have diabetes mellitus concurrently. Diabetes was the second-highest occurrence, with 49.45% (n=45) of patients receiving therapy for it. Also, at the time of surgery, 12.08 % (n=11) had CKD, according to KDIGO definition. Since acquired solitary kidney patients are more likely to experience rapidly declining renal function, they require continuous monitoring. Conclusions: Younger individuals are more prone to develop CKD slowly. Therefore, the clinician has to monitor issues like kidney stones or urinary tract infections.
{"title":"THE FOLLOW-UP OF PATIENTS WITH SURGICAL SOLITARY KIDNEY - THE UNDER-ESTIMATED ROLE OF COMORBIDITIES","authors":"C Pricop","doi":"10.22551/msj.2023.03.09","DOIUrl":"https://doi.org/10.22551/msj.2023.03.09","url":null,"abstract":"THE FOLLOW-UP OF PATIENTS WITH SURGICAL SOLITARY KIDNEY-THE UN-DERESTIMATED ROLE OF COBORBIDITIES (Abstract): In order to customize the follow-up plan and lower the risks of end-stage renal disease progression (ESRD), we set out to create a monitoring program for patients with surgical solitary kidneys. Additionally, by determining the underlying etiology and comorbidities (such as pre-existing CKD or Diabetes). 91 patients have been found who satisfy the inclusion requirements. Material and methods: There were 51 ladies and 40 guys among them. They ranged in age from 20 to 90. The average age was 60.69 years (SD +/- 15.87). There was no difference in the mean age between the genders (63.22 vs. 58.71, p=0.08). Kidney cancer (50.54%), upper urothelial tract carcinoma (25.27%), pyonephrosis (17.58%), and kidney trauma (6.59%) were the primary pathologies for which surgery was performed. The patients were also arbitrarily separated into three age groups: Group A, 20-40 years old; Group B, 41-60 years old; and Group C, over 60 years old. Results: One month after discharge, C-reactive protein increased (p=0.05), and eGFR decreased significantly (p=0.003). The most common comorbidity (74.72%; n=68) was arterial hypertension. Of these, 51.47% (n=35) have diabetes mellitus concurrently. Diabetes was the second-highest occurrence, with 49.45% (n=45) of patients receiving therapy for it. Also, at the time of surgery, 12.08 % (n=11) had CKD, according to KDIGO definition. Since acquired solitary kidney patients are more likely to experience rapidly declining renal function, they require continuous monitoring. Conclusions: Younger individuals are more prone to develop CKD slowly. Therefore, the clinician has to monitor issues like kidney stones or urinary tract infections.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RESPONSE-A FURTHER CHALLENGING CONSEQUENCE OF LIVER CIRRHOSIS (Abstract): The sustained virologic response (SVR) achieved by most patients treated with direct acting antivirals (DAAs) involves multiple benefits such as regression of fibrosis and improvement in liver function. However, DAAs therapy doesn’t eliminate the risk of thrombotic events. The aim of our study was to assess the prevalence of nontumoral portal vein thrombosis (PVT) after SVR and identification of risk factors associated with this complication. Material and methods: We retrospective analyzed a cohort of patients with HCV-related liver cirrhosis treated with paritaprevir/ritonavir, ombitasvir and dasabuvir (PrOD) ± ribavirin and ledipasvir/sofosbuvir (LED/SOF) ± ribavirin for 12/24 weeks, in a gastroenterology center from Romania, between October 2015 and December 2018. All patients with presumption of PVT were evaluated by abdominal ultrasound and confirmed by CT scan. Results: The study included 730 patients treated with DAAs, of which 35 were diagnosed with non-malignant PVT after-SVR (15 men and 20 women, mean age 57.86 ± 7.068 years), corresponding to a prevalence of 4.8%. The mean time from SVR to complication was 290.00 ± 116.639 days. Most patients with non-tumoral PVT after-SVR received LED/SOF (71.4%), while the rest received PrOD (28.6%). Twenty-four patients (68.6%) diagnosed with acute PVT and 11 patients (31.4%) with chronic PVT. During the study, an improvement in liver function was observed, with an improvement in the Child-Pugh and MELD score at the time of SVR; the evolution changes slightly at the 48-week assessment, with a slight increase in the proportion of patients with Child B and MELD ≥ 15. Conclusions: Occurrence of non-malignant PVT in patients with HCV-related liver cirrhosis treated with DAAs correspond to the natural evolution of the cirrhotic patient.
{"title":"NONTUMORAL PORTAL VEIN THROMBOSIS IN PATIENTS WITH HEPATITIS C VIRUS AND SUSTAINED VIROLOGICAL RESPONSE - A FURTHER CHALLENGING CONSEQUENCE OF LIVER CIRRHOSIS","authors":"Laura Huiban","doi":"10.22551/msj.2023.03.04","DOIUrl":"https://doi.org/10.22551/msj.2023.03.04","url":null,"abstract":"RESPONSE-A FURTHER CHALLENGING CONSEQUENCE OF LIVER CIRRHOSIS (Abstract): The sustained virologic response (SVR) achieved by most patients treated with direct acting antivirals (DAAs) involves multiple benefits such as regression of fibrosis and improvement in liver function. However, DAAs therapy doesn’t eliminate the risk of thrombotic events. The aim of our study was to assess the prevalence of nontumoral portal vein thrombosis (PVT) after SVR and identification of risk factors associated with this complication. Material and methods: We retrospective analyzed a cohort of patients with HCV-related liver cirrhosis treated with paritaprevir/ritonavir, ombitasvir and dasabuvir (PrOD) ± ribavirin and ledipasvir/sofosbuvir (LED/SOF) ± ribavirin for 12/24 weeks, in a gastroenterology center from Romania, between October 2015 and December 2018. All patients with presumption of PVT were evaluated by abdominal ultrasound and confirmed by CT scan. Results: The study included 730 patients treated with DAAs, of which 35 were diagnosed with non-malignant PVT after-SVR (15 men and 20 women, mean age 57.86 ± 7.068 years), corresponding to a prevalence of 4.8%. The mean time from SVR to complication was 290.00 ± 116.639 days. Most patients with non-tumoral PVT after-SVR received LED/SOF (71.4%), while the rest received PrOD (28.6%). Twenty-four patients (68.6%) diagnosed with acute PVT and 11 patients (31.4%) with chronic PVT. During the study, an improvement in liver function was observed, with an improvement in the Child-Pugh and MELD score at the time of SVR; the evolution changes slightly at the 48-week assessment, with a slight increase in the proportion of patients with Child B and MELD ≥ 15. Conclusions: Occurrence of non-malignant PVT in patients with HCV-related liver cirrhosis treated with DAAs correspond to the natural evolution of the cirrhotic patient.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EXCELLENT LONG-TERM NEGATIVE PREDICTIVE VALUE OF CAPSULE ENDOSCOPY IN SUSPECTED ISOLATED SMALL BOWEL CROHN’S DISEASE","authors":"Ana-Maria Singeap","doi":"10.22551/msj.2023.03.07","DOIUrl":"https://doi.org/10.22551/msj.2023.03.07","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FAILURE (Abstract): Aim : The aim of the present study is to discover new approaches for old drugs, targeting heart failure (HF), using in silico studies. Material and methods : Several old drugs, belong different chemical and therapeutical classes: oral hypoglycemic drugs (sulfonylurea), proton pump inhibitors, nonsteroidal anti-inflammatory drugs, statins, H 1 /H 2 antagonists, antineoplastic drugs, alfa-adrenergic agonists, vitamins and antioxidants, were tested for affinity to glycogen synthase kinase 3 beta (GSK-3β), using in silico molecular docking studies. In-dirubin-3’-monoxime (I3M) and adenylyl-imidodiphosphate (AMP-PNP), were used as GSK-3β reference inhibitors. Moreover, the drugs with the best docking score for GSK-3β, were included in an ADME-Tox study to predict their pharmacokinetic profile. Results: The used computational method was validated using RSMD variation (less than 2 Å) recorded for GSK-3β inhibitors (I3M and AMP-PNP). The results showed that the binding of drugs to GSK-3β involve direct hydrogen bonds and van der Waals interactions with key amino acids from active site, Lys85, Asp133, Val135, Glu137, Arg141, Gln185, Asp200 and Arg220. Conclusions : Based on in silico results, in term of affinity for GSK-3β and ADME Tox profile, several drugs have theoretical premises to have beneficial effects in HF and could be propose for repurposing approach, which look of finding new clinical indications for existing drugs
{"title":"IN SILICO SCREENING OF SOME OLD DRUGS FOR NEW APPROACHES IN HEART FAILURE","authors":"A.D. Sava","doi":"10.22551/msj.2023.03.18","DOIUrl":"https://doi.org/10.22551/msj.2023.03.18","url":null,"abstract":"FAILURE (Abstract): Aim : The aim of the present study is to discover new approaches for old drugs, targeting heart failure (HF), using in silico studies. Material and methods : Several old drugs, belong different chemical and therapeutical classes: oral hypoglycemic drugs (sulfonylurea), proton pump inhibitors, nonsteroidal anti-inflammatory drugs, statins, H 1 /H 2 antagonists, antineoplastic drugs, alfa-adrenergic agonists, vitamins and antioxidants, were tested for affinity to glycogen synthase kinase 3 beta (GSK-3β), using in silico molecular docking studies. In-dirubin-3’-monoxime (I3M) and adenylyl-imidodiphosphate (AMP-PNP), were used as GSK-3β reference inhibitors. Moreover, the drugs with the best docking score for GSK-3β, were included in an ADME-Tox study to predict their pharmacokinetic profile. Results: The used computational method was validated using RSMD variation (less than 2 Å) recorded for GSK-3β inhibitors (I3M and AMP-PNP). The results showed that the binding of drugs to GSK-3β involve direct hydrogen bonds and van der Waals interactions with key amino acids from active site, Lys85, Asp133, Val135, Glu137, Arg141, Gln185, Asp200 and Arg220. Conclusions : Based on in silico results, in term of affinity for GSK-3β and ADME Tox profile, several drugs have theoretical premises to have beneficial effects in HF and could be propose for repurposing approach, which look of finding new clinical indications for existing drugs","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"URTICARIA IN CHILDREN - A DISEASE IN DISGUISE","authors":"Alice Nicoleta Azoicai","doi":"10.22551/msj.2023.03.03","DOIUrl":"https://doi.org/10.22551/msj.2023.03.03","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135086039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EXPLORING THE RELATIONSHIP BETWEEN PSYCHOSOCIAL RISKS, BURNOUT LEVELS, AND EMOTIONAL INTELLIGENCE AMONG MEDICAL AND NON-MEDICAL PERSONNEL IN ROMANIAN MEDICAL UNITS","authors":"Roxana-Mihaela Claponea","doi":"10.22551/msj.2023.03.14","DOIUrl":"https://doi.org/10.22551/msj.2023.03.14","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FOR PROSTATIC ADENOCARCINOMA (Abstract): Renal function parameters, readily assessed through routine blood tests, have been largely unexplored in relation to prostate cancer. This study aims to investigate the associations between renal function parameters (creatinine, urea, estimated glomerular filtration rate-eGFR), both pre-and post-prostatectomy, and histopathological characteristics of prostate adenocarcinomas. Additionally, it evaluates potential correlations with prostate biochemical recurrence, offering insights into kidney function dynamics post-prostatectomy. Material and methods: We analyzed data from 72 patients with prostate adenocarcinoma who underwent radical prostatectomy. Histopathological reevaluation was conducted, including Gleason score, pT stage, prognostic grade groups, and biochemical recurrence assessment. Preoperative and postoperative renal parameters were recorded, and eGFR was calculated using the CKD-EPI formula. Statistical analysis was performed to assess associations. Results: Preoperative eGFR showed a significant association with Gleason score and prognostic grade groups (p<0.05). However, there were no significant correlations between renal parameters and biochemical recurrence or pT stage. Conclusions: This study emphasizes the potential utility of eGFR as a marker for identifying prostate adenocarcinomas with higher Gleason scores and prognostic grade groups. While the complexity of renal function dynamics in prostate cancer warrants further investigation, our findings contribute to understanding the intricate relationship between kidney function and prostate tumor behavior.
{"title":"RENAL FUNCTION DYNAMICS IN PATIENTS WITH RADICAL PROSTATECTOMY FOR PROSTATIC ADENOCARCINOMA","authors":"A.D. Timofte","doi":"10.22551/msj.2023.03.12","DOIUrl":"https://doi.org/10.22551/msj.2023.03.12","url":null,"abstract":"FOR PROSTATIC ADENOCARCINOMA (Abstract): Renal function parameters, readily assessed through routine blood tests, have been largely unexplored in relation to prostate cancer. This study aims to investigate the associations between renal function parameters (creatinine, urea, estimated glomerular filtration rate-eGFR), both pre-and post-prostatectomy, and histopathological characteristics of prostate adenocarcinomas. Additionally, it evaluates potential correlations with prostate biochemical recurrence, offering insights into kidney function dynamics post-prostatectomy. Material and methods: We analyzed data from 72 patients with prostate adenocarcinoma who underwent radical prostatectomy. Histopathological reevaluation was conducted, including Gleason score, pT stage, prognostic grade groups, and biochemical recurrence assessment. Preoperative and postoperative renal parameters were recorded, and eGFR was calculated using the CKD-EPI formula. Statistical analysis was performed to assess associations. Results: Preoperative eGFR showed a significant association with Gleason score and prognostic grade groups (p<0.05). However, there were no significant correlations between renal parameters and biochemical recurrence or pT stage. Conclusions: This study emphasizes the potential utility of eGFR as a marker for identifying prostate adenocarcinomas with higher Gleason scores and prognostic grade groups. While the complexity of renal function dynamics in prostate cancer warrants further investigation, our findings contribute to understanding the intricate relationship between kidney function and prostate tumor behavior.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"WEIGHT LOSS AND NUTRITIONAL STATUS IN YOUNG AND MIDDLE-AGED ADULTS: RATIONAL APPROACH AND HEALTH IMPLICATIONS","authors":"B. Huzum","doi":"10.22551/msj.2023.03.15","DOIUrl":"https://doi.org/10.22551/msj.2023.03.15","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135085490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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