用于癌症诊断的新型嵌入式中继透镜显微高光谱成像系统的研制——以口腔癌小鼠为例

Yao-Fang Hsieh, M. Ou‐Yang, J. Duann, J. Chiou, N. Chang, C. Jan, M. Tsai, Shuen-De Wu, Yung-Jiun Lin, Cheng-chung Lee
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引用次数: 7

摘要

研制了一种具有高光谱分辨率(标称光谱分辨率为2.8 nm)和空间分辨率(30 μm × 10 μm)的嵌入式中继透镜显微高光谱成像系统(ERL-MHSI),用于癌症诊断。ERL-MHSI系统具有透光模式和荧光模式。透射率可以为病理诊断提供形态学信息,细胞或组织的荧光可以为鉴别正常和异常提供特征标志。本文讨论了ERL-MHSI系统的发展,并通过20只小鼠早期口腔癌的体外诊断证明了该系统的能力。鉴别正常细胞和鳞状细胞癌(SCC)的最佳灵敏度为100%。鉴别正常细胞和SCC的最佳特异性为99%。鉴别正常细胞和非典型增生的最佳灵敏度为99%。鉴别正常细胞和非典型增生的最佳特异性为97%。本工作还利用分形维数对形态学信息进行分析,发现normal和SCC之间存在显著差异。
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Development of a Novel Embedded Relay Lens Microscopic Hyperspectral Imaging System for Cancer Diagnosis: Use of the Mice with Oral Cancer to Be the Example
This paper develops a novel embedded relay lens microscopic hyperspectral imaging system (ERL-MHSI) with high spectral resolution (nominal spectral resolution of 2.8 nm) and spatial resolution (30 μm × 10 μm) for cancer diagnosis. The ERL-MHSI system has transmittance and fluorescence mode. The transmittance can provide the morphological information for pathological diagnosis, and the fluorescence of cells or tissue can provide the characteristic signature for identification of normal and abnormal. In this work, the development of the ERL-MHSI system is discussed and the capability of the system is demonstrated by diagnosing early stage oral cancer of twenty mice in vitro. The best sensitivity for identifying normal cells and squamous cell carcinoma (SCC) was 100%. The best specificity for identifying normal cells and SCC was 99%. The best sensitivity for identifying normal cells and dysplasia was 99%. The best specificity for identifying normal cells and dysplasia was 97%. This work also utilizes fractal dimension to analyze the morphological information and find the significant different values between normal and SCC.
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