孟加拉国儿科患者处方药物相互作用评估

S. Ahmed, S. Yesmine, Mizanur Rahman, M. Shahriar
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摘要

药物相互作用(ddi)是一个重要的临床问题。在住院期间,婴儿、儿童和青少年通常暴露于不同的药物,增加了他们潜在的药物-药物相互作用(pddi)的风险。虽然据报道药物相互作用很常见,但孟加拉国儿科患者中这种相互作用的患病率只有很少的出版物。本研究试图估计在儿童医院接受治疗的儿童患者的pDDI暴露的患病率和特征。这项观察性回顾性研究是在2019年1月至2019年8月期间对达卡一家儿童医院收治的155名患者进行的。采用Medscape药物相互作用检测仪对患者用药情况进行分析。对处方进行人口统计学特征、医疗和详细用药史分析。评估药物-药物相互作用(ddi)的总数、类型和严重程度。共分析处方155张,平均用药年龄(2.12±2.08)岁,共记录pddi 25张。pDDI患病率为17%,其中药效学相互作用12例(48%),药代动力学相互作用10例(40%),机制未知3例(12%)。根据相互作用的严重程度,严重4例(18%),中度15例(55%),轻微6例(27%)。ddi的发生与用药次数有显著相关(r=0.912, p<0.05)。目前的研究已经确定了pddi,并记录了儿科患者的相互作用。它强调了筛查儿科患者pddi处方和主动监测已确定风险因素的患者的必要性,以促进发现和预防可能的不良药物相互作用。孟加拉国药学杂志24(2):91-98,2021
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Assessment of Interactions of Drugs Prescribed for Pediatric Patients in Bangladesh
Drug-drug interactions (DDIs) represent an important clinical problem. During inpatient admissions, infants, children, and adolescents are typically exposed to different medications, increasing their risk of potential drug-drug interactions (pDDIs). While drug interactions are reported to be common, there are only few publications of the prevalence of such interactions among pediatric patients in Bangladesh. The present study tries to estimates the prevalence and characteristics of pDDI exposure of pediatric patients treated in children’s hospitals. This observational retrospective study was carried out on 155 patients admitted to a children’s hospital located at Dhaka during January 2019 to August 2019. The medications of the patients were analyzed for pDDIs by using Medscape drug interaction checker. The prescriptions were analyzed for demographic characteristics, medical and detailed drug history. Drug-drug interactions (DDIs) were evaluated for total numbers, types and severity of DDIs. Total 155 prescriptions with mean age 2.12±2.08 years were analyzed and a total of 25 pDDIs were recorded. The prevalence of pDDI was 17%, of which 12 (48%) were pharmacodynamic interactions, 10 (40%) were pharmacokinetic interactions and 3 (12%) of unknown mechanism. According to the severity of interaction, 4 (18%) cases were categorized as serious, 15 (55%) cases as moderate and 6 (27%) cases as minor. The occurrence of DDIs were significantly associated (r=0.912, p<0.05) with the number of drugs prescribed. The present study has identified pDDIs and also documented interactions in pediatrics patients. It has highlighted the need for screening prescriptions of pediatric patients for pDDIs and proactive monitoring of patients who have identified risk factors in order to promote detection and prevention of possible adverse drug interactions. Bangladesh Pharmaceutical Journal 24(2): 91-98, 2021
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