拔牙前应该停用抗血小板药物吗?

N. Altiparmak, S. S. Akdeniz, B. Bayram, K. Araz
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引用次数: 0

摘要

目的:本研究的目的是评估拔牙后未中断单抗或双抗血小板治疗的患者出血的发生率。材料和方法:本研究共包括195名连续受试者,于2016年2月至5月在巴斯肯特大学口腔颌面外科由同一名合格牙医进行拔牙。患者分为三组(每组65例):双抗血小板治疗(乙酰水杨酸和氯吡格雷),第一对照组(不进行抗血小板或抗凝治疗)和第二对照组(拔牙前3-10天停止抗血小板治疗)。结果:两组患者在性别分布、平均年龄、拔牙类型、拔牙数量等方面均无统计学差异。研究组术后出血发生率高于对照组,但差异无统计学意义(p>0.05)。在研究组中,双重治疗的患者术后出血发生率高于单独使用乙酰水杨酸或氯吡格雷的患者;但差异无统计学意义(p>0.05)。结论:本研究结果提示拔牙前无需停止单次或双次抗血小板治疗。
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Should Antiplatelet Drugs Stopped Before Dental Extraction?
Objective: The aim of this study was to evaluate the incidence of postoperative bleeding after dental extraction in patients without interruption of single or dual antiplatelet therapy. Material and Metods: The study comprised a total of 195 consecutive subjects who underwent dental extractions performed by the same qualified dentist in Baskent University Department of Oral and Maxillofacial Surgery between the date of February and May 2016. Patients were divided into three groups (n=65 in each group): dual antiplatelet therapy (acetylsalicylic acid and clopidogrel), first control (no antiplatelet or anticoagulant therapy) and second control group (antiplatelet therapy ceased for 3-10 days prior to dental extraction). Results: There was no significant difference in sex distribution, mean age, or in the types or number of teeth extracted between the groups. The incidence of postoperative bleeding was higher in the study group than in the control groups, but the difference was not significant (p>0.05). In the study group, the incidence of postoperative bleeding was higher in patients on dual therapy than in those on acetylsalicylic acid alone or clopidogrel alone; however, the differences were not significant (p>0.05). Conclusion: The findings of the present study suggest that there is no need to stop single or dual antiplatelet therapy prior to dental extraction.
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Turkiye Klinikleri Cardiovascular Sciences
Turkiye Klinikleri Cardiovascular Sciences Medicine-Cardiology and Cardiovascular Medicine
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