组织工程和生长因子:最新证据

P. Hassanzadeh
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引用次数: 13

摘要

在难以治疗的疾病中,传统的药物或医疗器械可以减轻症状,但不能逆转病情。近年来,对组织工程领域的兴趣日益浓厚,产生了不同的体外组织生长或体内损伤组织的增强修复策略。组织工程治疗或诊断应用的核心方法是以多种方式利用活细胞的能力。在这种情况下,理想细胞的鉴定和生物材料的开发,包括用于修复、替换或再生受损组织的支架的潜在应用,显得至关重要。同时,成功的组织工程往往依赖于将生长因子输送到再生组织中。生长因子是一种多功能肽,在细胞增殖、趋化、细胞间信号、血管生成、细胞外基质形成以及组织完整性重建等多种生理过程中发挥着重要作用。为了模拟自然组织形态发生或再生过程中生长因子产生的内源性特征,需要开发复杂的生长因子传递机制。这篇综述强调了组织工程的一般方面,以及将生长因子纳入生物材料及其递送到损伤组织的方法。生物医学评论2012;23: 19-35。
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Tissue engineering and growth factors: updated evidence
In difficult-to-treat disorders, the traditional pharmacological agents or medical devices alleviate the symptoms but do not reverse the condition. In recent years, the increasing interest into the field of tissue engineering has generated different strategies for tissue growth in vitro or the enhanced repair of damaged tissues in vivo. The core approach of tissue engineering for either therapeutic or diagnostic applications is the ability to exploit living cells in a variety of ways. In this context, identification of the ideal cells and development of biomaterials including the scaffolds for potential applications in the repair, replacement, or regeneration of damaged tissues appear crucial. Meanwhile, successful tissue engineering is often dependent on the delivery of growth factors to the regenerating tissues. Growth factors are multifunctional peptides which play fundamental roles in a wide variety of physiological processes including cell proliferation, chemotaxis, intercellular signalling, angiogenesis and the formation of extracellular matrix, also the re-establishment of tissue integrity. In order to mimic the endogenous profile of growth factor production during the natural tissue morphogenesis or regeneration, the sophisticated mechanisms of growth factor delivery should be developed. This review highlights the general aspects of tissue engineering along with the approaches taken to incorporate growth factors within the biomaterials and their delivery to injured tissue. Biomedical Reviews 2012; 23: 19-35.
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