血小板-淋巴细胞比率和中性粒细胞-淋巴细胞比率作为终末期慢性肝病患者早期死亡率的预测指标

Syifa Mustika, Affa Kiysa Waafi
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引用次数: 1

摘要

背景:慢性肝病(CLD)常导致致命的并发症。child - turcote - pugh (CTP)评分是死亡率的最早预测指标,但终末期肝病模型(MELD)评分更为客观。研究表明,血小板-淋巴细胞比率(PLR)和中性粒细胞-淋巴细胞比率(NLR)可以成为慢性肝病死亡率的预测指标。我们的目的是研究NLR和PLR作为CLD的早期死亡率预测因子,并与CTP和MELD评分进行比较。方法:回顾性观察队列研究。我们招募了来自印度尼西亚Saiful Anwar医院的CLD(肝硬化和肝细胞癌)患者。有关PLR、NLR、CTP和MELD评分的数据来自医疗记录。参与者随访30天以确定生存率。结果:90例患者被纳入研究。30 d内死亡31例(34.4%)。HCC患者的死亡率高于肝硬化患者。虽然NLR与CTP具有相似的敏感性(51.6%),但PLR (p 0.956)和NLR (p 0.087)都不能比CTP (p 0.001)或MELD评分(p 0.002)更好地预测死亡率。与PLR相反,NLR与MELD和CTP得分呈正相关。结论:与PLR相反,NLR与疾病严重程度呈正相关,与CTP和MELD评分相比,NLR有可能作为慢性肝病患者早期死亡率的预测因子。但PLR不能同时代替CTP和MELD评分。
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Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio as Early Mortality Predictors for Patients with End-Stage Chronic Liver Disease
Background: Chronic liver disease (CLD) often results in fatal complications. Child-Turcotte-Pugh (CTP) score is the earliest predictor of mortality but the Model for End-Stage Liver Disease (MELD) score is more objective. Studies showed platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) could become mortality predictors for chronic liver disease. We aimed to investigate NLR and PLR as early mortality predictors for CLD, in comparison with CTP and MELD scores. Method: This was a retrospective observational cohort study. We recruited patients with CLD (liver cirrhosis and hepatocellular carcinoma), from Saiful Anwar Hospital, Indonesia. Data regarding PLR, NLR, CTP, and MELD scores were obtained from the medical records. Participants were followed for 30 days to determine survival. Results: Ninety patients were recruited in the study. There were 31 deaths (34.4%) in 30 days. Mortality was higher in HCC patients than liver cirrhosis. Although NLR had similar sensitivity with CTP (51.6%), neither PLR (p 0.956) nor NLR (p 0.087) could significantly better predict mortality than CTP (p 0.001) or MELD scores (p 0.002). In opposite to PLR, NLR had a positive correlation with MELD and CTP scores. Conclusion: On the contrary to the PLR, the NLR positively correlated with the severity of the disease, NLR had the potential as a predictor of early mortality for patients with chronic liver disease as compared to CTP and MELD scores. But PLR could not substitute both CTP and MELD scores.
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