双层褪黑素片剂配方:一种新的治疗方法

IF 1.6 4区医学 Q3 PRIMARY HEALTH CARE Primary Health Care Research and Development Pub Date : 2020-01-01 DOI:10.15761/HPC.1000192

Herminia Castán Urbano, Mª. Adolfina Ruiz Martínez, M. Rodriguez, Elena Ortega Martínez y, M. E. M. Hernández

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引用次数: 0

摘要

褪黑素是一种具有多种作用的激素，其中一种作用是，在适当的管理下，能够控制体重，预防与肥胖和糖尿病相关的心血管疾病。因此，这项工作的重点是设计和制造双层片剂，通过顶层，可以在给药后更快地释放褪黑激素，并通过另一层，随着时间的推移提供延长的释放。从技术角度对片剂进行了表征，并进行了崩解和释放试验，以帮助确定其生物制药特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bilayer melatonin tablet formulation: a novel approach to therapeutic efficacy

Melatonin is a hormone with multiple actions, one of which, with proper administration, is the ability to control weight and prevent cardiovascular illnesses associated with obesity and diabetes. So, this work focuses on the design and creation of bilayer tablets which, through the top layer, permit a faster melatonin release after administration and, through the other layer, offer an extended release over time. The tablets are characterized from a technological perspective and have been subjected to disintegration and release tests to help determine their biopharmaceutical profile.

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来源期刊

Primary Health Care Research and Development PRIMARY HEALTH CARE-

CiteScore

2.60

自引率

6.20%

发文量

119

审稿时长

33 weeks

期刊介绍： Primary Health Care Research & Development is aimed specifically at both researchers and practitioners in primary health care, bridging the gap between the two areas. It provides a forum for the publication of international, interdisciplinary research and development in primary health care. It is essential reading for all involved in primary care: nurse practitioners, GPs and health service managers; professional and local groups in community health; researchers and academics; purchasers of primary health care services; allied health practitioners in secondary services and health-related consumer groups.