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引用次数: 8

摘要

一些研究表明,冠状动脉微循环的功能和结构异常发生在许多临床疾病中,包括动脉高血压,这可能导致心血管疾病的发病率和死亡率。这种功能障碍是由血管和血管外结构的重塑以及冠状动脉血流动力学异常引起的。降压治疗是否能导致冠状动脉微血管的反向重构仍有待确定。最近一项对动脉高血压和左心室肥厚患者的初步研究结果显示,使用培哚普利和吲达帕胺联合治疗6个月后,血压和左心室质量显著降低,静息和充血心肌血流量增加,采用正电子发射断层扫描无创测量。这表明,冠状动脉微血管功能障碍可以通过这些药物治疗逆转,并可能有助于预防这些患者的缺血性心脏病。
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From microcirculation to cardiac event: protection with Preterax.
Several studies have demonstrated that abnormalities in the function and structure of the coronary microcirculation occur in many clinical conditions, including arterial hypertension in which it might contribute to cardiovascular morbidity and mortality. This dysfunction is caused by remodelling of vascular and extravascular structures as well as abnormal coronary haemodynamics. Whether antihypertensive treatment can lead to reverse remodelling of the coronary microvasculature remains to be determined. The preliminary results of a recent study in patients with arterial hypertension and left ventricular hypertrophy show that 6 months' treatment with a combination of perindopril and indapamide is accompanied by a significant decrease in blood pressure and left ventricular mass and an increase in resting and hyperaemic myocardial blood flow measured non-invasively with positron emission tomography. This suggests that coronary microvascular dysfunction can be reversed by treatment with these drugs and might contribute to the prevention of ischaemic heart disease in these patients.
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