动力学分光光度法测定制剂中盐酸非索非那定的含量

S. Ashour, Mouhammed Khateeb
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引用次数: 7

摘要

建立了一种简便、灵敏的动力学分光光度法测定原料药和制剂中盐酸非索非那定的含量。以碱性高锰酸钾为氧化剂,对非索非那定在室温下的氧化反应进行了动力学研究。用分光光度法测定了锰离子在610 nm处形成的吸光度的增加。采用初始速率法和固定时间法(15分钟)构建标定图。研究了该方法的所有反应条件。初始速率法和固定时间法的线性范围为2.5 ~ 50.0 μ mL−1,检出限为0.055 μ mL−1。该方法成功地用于制剂中非索非那定的含量测定;加样回收率为99.98 ~ 101.96%。所得结果与官方方法进行了统计比较,在准确度和精密度上均无显著差异。
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New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations
A simple and sensitive kinetic spectrophotometric method was developed for the determination of fexofenadine hydrochloride in bulk and pharmaceutical preparations. The method is based on a kinetic investigation of the oxidation reaction of fexofenadine using alkaline potassium permanganate as an oxidizing agent at room temperature. The reaction is followed spectrophotometrically by measuring the increase of absorbance owing to the formation of manganate ion at 610 nm. The initial rate and fixed time (at 15 min) methods are utilized for construction of calibration graphs. All the reaction conditions for the proposed method have been studied. The linearity range was found to be 2.5–50.0 μg mL−1 with detection limit of 0.055 μg mL−1 for both initial rate and fixed time methods. The proposed method was applied successfully for the determination of fexofenadine in pharmaceutical formulations; the percentage recoveries were 99.98–101.96%. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.
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