热响应分子印迹聚合物包覆磁性热种子的研究

IF 4.2 3区 材料科学 Q2 MATERIALS SCIENCE, COMPOSITES Nanocomposites Pub Date : 2021-01-02 DOI:10.1080/20550324.2021.2008206
T. Kubo, Miwa Shimonaka, Y. Watabe, Kazunari Akiyoshi, J. Balachandran, K. Otsuka
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引用次数: 0

摘要

摘要:我们设想了一种新型的热响应分子印迹聚合物(MIP)和磁热种子(MTS)的杂交载体,该载体在交流磁场下表现出发热能力。与以往文献相比,我们对MIP和MTS进行了修改,提高了混合载体的可行性,简单地说,我们要实现MTS的精确尺寸控制和更窄的尺寸分布,以及更高的分子识别/释放能力。首先,通过控制磁芯的产生,成功制备了在交流磁场下具有较大发热能力的均匀大小的粒子。然后,以n -碳苯氧基-l-谷氨酸为假模板制备了靶向选择性吸附培美曲塞(PMX)的MIP。最后,通过配体交换法引入乙烯基作为甲基丙烯酸,初步考察了MTS和mip等效聚合物涂层的杂化反应。图形抽象
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Study on magnetic thermal seeds coated with thermal-responsive molecularly imprinted polymers
Abstract We conceived a novel hybrid carrier of a thermal-responsive molecularly imprinted polymer (MIP) and a magnetic thermal seed (MTS) that showed a heat-generating ability under an alternate current (AC) magnetic field. Compared to our previous publications, we modify both the MIP and MTS to improve the feasibility for the hybrid carrier, briefly we have to achieve the accurate size control and narrower size distribution of MTS, and higher molecular recognition/release ability of MIP. Firstly, uniformly sized particles which are expected to show a large heat-generating ability under an AC magnetic field were successfully prepared by controlling the core creation. Then, an MIP targeted for selective adsorption of pemetrexed (PMX), a well-known anti-cancer drug, was prepared using N-carbobenzoxy-l-glutamic acid as a pseudo template. Finally, the preliminary hybridization of the MTS and the MIP-equivalent polymer coating was examined by introducing vinyl groups as methacrylic acid using a ligand exchanging method. Graphical Abstract
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来源期刊
Nanocomposites
Nanocomposites Multiple-
CiteScore
7.40
自引率
15.20%
发文量
18
审稿时长
16 weeks
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