ANTIOXIDANT ACTIVITY TEST OF THE RED YEAST RICE EXTRACT AND THE FORMULATION IN A CREAM PREPARATIONS ANDIT’S PENETRATION AND SAFETY TEST AT RABBIT

Red yeast rice is one of thefoodstuff that contains flavonoid compounds which are useful as natural antioxidants. One attempt to overcome wrinkles is with antioxidants. The easy way to apply red yeast rice can be make in an extract that are formulated in cream preparations. This study aims to determine the antioxidant activities of Red yeast rice extract and its formulation in cream dosage form and the test of penetration and safety. Red yeast rice extract obtained by the method of maseration using ethanol 96% as a solvent. The cream is make in 3 formula, where the first formula as a negative control, second formula is cream of red yeast rice extract and third formula is cream of red yeast ricemicroemulsion. The antioxidant activity tested by DPPH method, the penetrationstrengthtested by Franz difussionmethod and the safety by primary and ocular irritation test.Research results demonstrated that red yeast rice extract had activity as antioxidant with the IC50 value was 2,60 ppm < 50 ppm (strong antioxidant)  and microemulsion cream had penetrationstrength greater than red yeast rice extractcream. And the results of the primary irritation test showed that the cream is very little irritate and the results of the ocular irritation test cream does not irritate the eyes.