ABSTRAKSwamedikasi adalah pemilihan dan penggunaan obat oleh individu atau anggota keluarga tanpa instruktur okter, untuk mengobati kondisi yang dikenali ataupun didiagnosis sendiri. Analgetic atau yang sering disebut dengan obat penghalang rasa nyeri tanpa menghilangkan kesadaran. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon, untuk mengetahui persepsi siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon, untuk mengetahui tingkat tingkat pengetahuan dan persepsi siswa terhadap swamedikasi obat analgetik berdasarkan karakteristik siswa, dan untuk mengetahui tingkat pengetahuan dan persepsi siswa terhadap swamedikasi obat analgetik berdasarkan indikator soal yang dinilai. Metode penelitian ini adalah penelitian kuantitatif dengan menggunakan desaain deskriptif. Teknik pengambilan sampel menggunakan Teknik purposive sampling. Pengumpulan data menggunakan e-quisioner (google form) yang diberikan kepada 82 respponden yang memenuhi kriteria inklusi dan ekslusi. Teknik analisa data penelitian ini menggunakan analisis deskriptif. Hasil penelitian tingkat pengetahuan dan persepsi siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon diketahui tingkat pengetahuan memperoleh nilai rata-rata 78,96% termasuk kedalam kategori baik. Dan persepsi siswa memperoleh nilai rata-rata 83,63% termasuk kedalam kategori sangat baik. Berdasarkan karakteristik responden yang mempunyai pengetahuan baik dan persepsi dangat baik paling banyak terdapat pada usia 16 tahun, jenis kelamin perempuan, pekerjaan orangtua sebagai karyawan swasta, nyeri yang di derita responden 1 bulan terkahir yaitu nyeri badan/otot, Riwayat penggunaan obat yaitu parasetamol dan tempat mendapatkan obat yaitu Apotek. Tingkat pengetahuan siswa tentang swamedikasi obat analgetik berdasarkan indicator soal yang dinilai dengan benar yaitu : 78,66% pada indikator tingkat keamanan dan ketepatan penggunaan obat, 74,39% pada indikator dosis obat, 93,9% pada indikator kegunaan obat obat, 64,63% pada indikator cara penggunaan obat 74,39% pada inidkator efek samping obat, 89,02% pada inidkator cara penyimpanan, 97,56% pada indicator waktu kadaluwarsa obat, dan 64,63% pada inidkator pemusnahan obat.Kata kunci: Swamedikasi, Analgetik, Tingkat Pengetahuan, Persepsi
{"title":"Analisis Tingkat Pengetahuan dan Persepsi Swamedikasi Obat Analgetik pada Siswa di SMAN 3 Cirebon","authors":"Febia Nurrahma Berlian, Ahmad Azrul Zuniarto, Siti Pandanwangi, Encis Rubihatlan, Ajni Minhatul Maula, Azriel Farhan Alfawwaz, Akil Salafi, Deby Sri Virgianti","doi":"10.37013/jf.v12i1.216","DOIUrl":"https://doi.org/10.37013/jf.v12i1.216","url":null,"abstract":"ABSTRAKSwamedikasi adalah pemilihan dan penggunaan obat oleh individu atau anggota keluarga tanpa instruktur okter, untuk mengobati kondisi yang dikenali ataupun didiagnosis sendiri. Analgetic atau yang sering disebut dengan obat penghalang rasa nyeri tanpa menghilangkan kesadaran. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon, untuk mengetahui persepsi siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon, untuk mengetahui tingkat tingkat pengetahuan dan persepsi siswa terhadap swamedikasi obat analgetik berdasarkan karakteristik siswa, dan untuk mengetahui tingkat pengetahuan dan persepsi siswa terhadap swamedikasi obat analgetik berdasarkan indikator soal yang dinilai. Metode penelitian ini adalah penelitian kuantitatif dengan menggunakan desaain deskriptif. Teknik pengambilan sampel menggunakan Teknik purposive sampling. Pengumpulan data menggunakan e-quisioner (google form) yang diberikan kepada 82 respponden yang memenuhi kriteria inklusi dan ekslusi. Teknik analisa data penelitian ini menggunakan analisis deskriptif. Hasil penelitian tingkat pengetahuan dan persepsi siswa tentang swamedikasi obat analgetik di SMAN 3 Cirebon diketahui tingkat pengetahuan memperoleh nilai rata-rata 78,96% termasuk kedalam kategori baik. Dan persepsi siswa memperoleh nilai rata-rata 83,63% termasuk kedalam kategori sangat baik. Berdasarkan karakteristik responden yang mempunyai pengetahuan baik dan persepsi dangat baik paling banyak terdapat pada usia 16 tahun, jenis kelamin perempuan, pekerjaan orangtua sebagai karyawan swasta, nyeri yang di derita responden 1 bulan terkahir yaitu nyeri badan/otot, Riwayat penggunaan obat yaitu parasetamol dan tempat mendapatkan obat yaitu Apotek. Tingkat pengetahuan siswa tentang swamedikasi obat analgetik berdasarkan indicator soal yang dinilai dengan benar yaitu : 78,66% pada indikator tingkat keamanan dan ketepatan penggunaan obat, 74,39% pada indikator dosis obat, 93,9% pada indikator kegunaan obat obat, 64,63% pada indikator cara penggunaan obat 74,39% pada inidkator efek samping obat, 89,02% pada inidkator cara penyimpanan, 97,56% pada indicator waktu kadaluwarsa obat, dan 64,63% pada inidkator pemusnahan obat.Kata kunci: Swamedikasi, Analgetik, Tingkat Pengetahuan, Persepsi","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Vitamin C is an essential water-soluble vitamin that is widely used as a body supplement. Misuse of the dosage will cause unwanted side effects such as nausea vomiting, diarrhea, increasing the risk of diabetes. Purpose: This study is to find out an overview of the level of knowledge on self-medicating the use of vitamin C for D III Pharmacy students of STIKes Widya Dharma Husada Tangerang during the Covid-19 pandemic. Method: This study is a descriptive study with 96 respondents taken by the cross-sectional method. Data were obtained through questionnaires and analyzed using percentages. Results: The results obtained in this study are the characteristics of respondents based on age Most of them are found at the age of 17-25 years, namely 87.5%, based on gender Most of them are found in women, namely 84.37%, based on work more than half of them are found in those who are not working, namely 52.08%, and based on a history of exposure to covid-19 more than half of them are found in those who have been exposed to covid-19, namely 73.96%, while the characteristics of respondents' knowledge about the use of well-informed vitamin C were highest based on the age of 17-25 years as much as 84.37%, in the female sex as much as 81.25%, in unemployed work as much as 50%, in the history of exposure to covid-19 who had been exposed to covid-19 as much as 70.83%. Conclusion: The results of this study show that the concentration of the level of knowledge on self-medicating the use of vitamin C for D III Pharmacy students of STIKes Widya Dharma Husada Tangerang during the Covid-19 pandemic was 96.88% included in the "Good" category.
背景：维生素 C 是人体必需的水溶性维生素，被广泛用作身体补充剂。滥用维生素 C 会引起恶心、呕吐、腹泻等副作用，增加患糖尿病的风险。目的：本研究旨在了解在 Covid-19 大流行期间，丹吉尔 STIKes Widya Dharma Husada 的 D III 级药剂学学生对自行服用维生素 C 的了解程度。 研究方法本研究是一项描述性研究，采用横断面法对 96 名受访者进行调查。数据通过问卷调查获得，并使用百分比进行分析。研究结果本研究得出的结果是受访者的年龄特征：大多数受访者的年龄在 17-25 岁之间，占 87.5%；性别特征：大多数受访者为女性，占 84.37%；工作特征：超过一半的受访者为非在职者，占 52.08%；科威-19 接触史特征：超过一半的受访者曾接触过科威-19，占 73.96%。96%，而受访者对使用知情维生素 C 的认知特点中，年龄在 17-25 岁的受访者比例最高，达 84.37%，性别为女性的受访者比例最高，达 81.25%，没有工作的受访者比例最高，达 50%，有接触过可威-19 的历史的受访者比例最高，达 70.83%。结论本研究结果表明，STIKes Widya Dharma Husada Tangerang 的 D III 级药剂学学生在 Covid-19 大流行期间使用维生素 C 进行自我治疗的知识水平集中度为 96.88%，属于 "良好 "类别。
{"title":"AN OVERVIEW OF THE LEVEL OF KNOWLEDGE ON SELF-MEDICATING VITAMIN C STUDENTS D III PHARMACY STIKES WDH TANGERANG DURING THE COVID-19 PANDEMIC","authors":"Anis Dwi Kristiyowati","doi":"10.37013/jf.v12i1.201","DOIUrl":"https://doi.org/10.37013/jf.v12i1.201","url":null,"abstract":"Background: Vitamin C is an essential water-soluble vitamin that is widely used as a body supplement. Misuse of the dosage will cause unwanted side effects such as nausea vomiting, diarrhea, increasing the risk of diabetes. Purpose: This study is to find out an overview of the level of knowledge on self-medicating the use of vitamin C for D III Pharmacy students of STIKes Widya Dharma Husada Tangerang during the Covid-19 pandemic. Method: This study is a descriptive study with 96 respondents taken by the cross-sectional method. Data were obtained through questionnaires and analyzed using percentages. Results: The results obtained in this study are the characteristics of respondents based on age Most of them are found at the age of 17-25 years, namely 87.5%, based on gender Most of them are found in women, namely 84.37%, based on work more than half of them are found in those who are not working, namely 52.08%, and based on a history of exposure to covid-19 more than half of them are found in those who have been exposed to covid-19, namely 73.96%, while the characteristics of respondents' knowledge about the use of well-informed vitamin C were highest based on the age of 17-25 years as much as 84.37%, in the female sex as much as 81.25%, in unemployed work as much as 50%, in the history of exposure to covid-19 who had been exposed to covid-19 as much as 70.83%. Conclusion: The results of this study show that the concentration of the level of knowledge on self-medicating the use of vitamin C for D III Pharmacy students of STIKes Widya Dharma Husada Tangerang during the Covid-19 pandemic was 96.88% included in the \"Good\" category.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diarrhea is a disease whose existence is still a global health problem, including Indonesia. Diarrhea is in the top 10 diseases that still occur frequently and is ranked 5th in the Osing Tribe. For the treatment of diarrhea, the Osing tribe still uses plants as medicinal plants that are used for generations. This study was conducted to examine how ethnopharmacy in the Osing tribe is intended as a preliminary study for the development of traditional medicine carried out by the Osing tribe as traditional medicine/phytopharmaca. This research is a descriptive study using qualitative methods with sampling techniques using snowball sampling through open-ended interviews by filling out informant information sheets and involving 22 informants from the Osing Tribe, Krajan hamlet, Kemiren, Glagah, Banyuwangi, East Java. The results of the ethnopharmaceutical research in the Osing Tribe showed that there were 8 types of plants and an analysis was carried out using ICF (Informant Consensus Factor) with the results of 0.6 being interpreted as being trusted and used as a hereditary treatment, PPV (Plant Part Value) to calculate the plant part used. with a yield of 50% leaves, 23% fruit, 27% rhizome and FL (Fidelity Level) to determine the types of plants most often used in treating diarrhea with the highest yield of 100%, including Psidium guajava L and Manihot esculenta.
{"title":"Kajian Etnofarmasi Penggunaan Tumbuhan Obat Sebagai Alternatif Pengobatan Diare Oleh Masyarakat Suku Osing Dusun Krajan","authors":"Amir Sanjaya, H. Hartono, T. D. Anggraini","doi":"10.37013/jf.v12i1.203","DOIUrl":"https://doi.org/10.37013/jf.v12i1.203","url":null,"abstract":"Diarrhea is a disease whose existence is still a global health problem, including Indonesia. Diarrhea is in the top 10 diseases that still occur frequently and is ranked 5th in the Osing Tribe. For the treatment of diarrhea, the Osing tribe still uses plants as medicinal plants that are used for generations. This study was conducted to examine how ethnopharmacy in the Osing tribe is intended as a preliminary study for the development of traditional medicine carried out by the Osing tribe as traditional medicine/phytopharmaca. This research is a descriptive study using qualitative methods with sampling techniques using snowball sampling through open-ended interviews by filling out informant information sheets and involving 22 informants from the Osing Tribe, Krajan hamlet, Kemiren, Glagah, Banyuwangi, East Java. The results of the ethnopharmaceutical research in the Osing Tribe showed that there were 8 types of plants and an analysis was carried out using ICF (Informant Consensus Factor) with the results of 0.6 being interpreted as being trusted and used as a hereditary treatment, PPV (Plant Part Value) to calculate the plant part used. with a yield of 50% leaves, 23% fruit, 27% rhizome and FL (Fidelity Level) to determine the types of plants most often used in treating diarrhea with the highest yield of 100%, including Psidium guajava L and Manihot esculenta.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prashinta Nita Damayanti, F. P. Luhurningtyas, Lyna Lestari Indrayati
Parijoto (Medinilla speciosa) has a wide range of pharmacological activities due to its secondary metabolite content, especially flavonoid, and phenolic compounds. Flavonoid and phenolic compounds have a major role in human health with their activities as antioxidants, anti-inflammatories, antimicrobials, etc. This study aimed to determine the total levels of phenolic and flavonoid compounds from the ethanol extract of Parijoto fruit. Parijoto fruit is obtained from Bandungan, Semarang Regency, Central Java. Extraction was carried out by maceration method with 70% ethanol solvent then concentrated using a rotary evaporator. The total phenolic and flavonoid content amount was determined using the colorimetric method with Folin-ciocalteau complex reagent on phenolic with gallic acid as the reference standard and AlCl3 complex reagent on flavonoids with quercetin as the reference standard. Absorbance was measured using a UV-Vis spectrophotometer. The results showed that the color of the viscous extract of Parijoto fruit was dark brown with a yield of 6.67% w/w. The total phenolic content of the ethanol extract of Parijoto fruit was 21.67 µgGAE/g extract and the total flavonoid content was 9.21 µg QE/g extract.
{"title":"Penetapan Kadar Fenolik dan Flavonoid Total Ekstrak Etanol Buah Parijoto (Medinilla speciosa Blume) dengan Metode Spektrofotometri UV-Vis","authors":"Prashinta Nita Damayanti, F. P. Luhurningtyas, Lyna Lestari Indrayati","doi":"10.37013/jf.v12i1.222","DOIUrl":"https://doi.org/10.37013/jf.v12i1.222","url":null,"abstract":"Parijoto (Medinilla speciosa) has a wide range of pharmacological activities due to its secondary metabolite content, especially flavonoid, and phenolic compounds. Flavonoid and phenolic compounds have a major role in human health with their activities as antioxidants, anti-inflammatories, antimicrobials, etc. This study aimed to determine the total levels of phenolic and flavonoid compounds from the ethanol extract of Parijoto fruit. Parijoto fruit is obtained from Bandungan, Semarang Regency, Central Java. Extraction was carried out by maceration method with 70% ethanol solvent then concentrated using a rotary evaporator. The total phenolic and flavonoid content amount was determined using the colorimetric method with Folin-ciocalteau complex reagent on phenolic with gallic acid as the reference standard and AlCl3 complex reagent on flavonoids with quercetin as the reference standard. Absorbance was measured using a UV-Vis spectrophotometer. The results showed that the color of the viscous extract of Parijoto fruit was dark brown with a yield of 6.67% w/w. The total phenolic content of the ethanol extract of Parijoto fruit was 21.67 µgGAE/g extract and the total flavonoid content was 9.21 µg QE/g extract.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n-hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti-inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage
{"title":"Anti-Inflammatory Test of Topical Cream Preparations from Ethyl Acetate Fraction of Johar Leaves (Cassia siamea L.) in White Mice","authors":"Audri Nandia Apriyanti, Diah Pratimasari, Eka Wisnu Kusuma","doi":"10.37013/jf.v12i1.223","DOIUrl":"https://doi.org/10.37013/jf.v12i1.223","url":null,"abstract":"Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n-hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti-inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acne vulgaris atau jerawat dapat disebabkan oleh bakteri, salah satunya Staphylococcus epidermidis yang akan menghasilkan enzim lipolitik yang mengubah sebum menjadi massa padat, kemudian akan menyumbat saluran kelenjar sebasea. Daun pala mengandung senyawa saponin, triterpenoid, tanin, dan flavonoid sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui daya hambat ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap pertumbuhan Staphylococcus epidermidis. Penelitian ini menggunakan metode penelitian deskriptif eksperimental untuk mengetahui efektivitas antibakteri ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap Staphylococcus epidermidis. Sumber data penelitian ini adalah data primer yaitu berdasarkan hasil zona hambat terhadap Staphylococcus epidermidis dengan pemberian ekstrak etanol daun pala (Myristica fragrans Houtt) dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun pala dapat digunakan sebagai antibakteri terhadap Staphylococcus epidermidis. Rata-rata diameter zona hambat ekstrak daun pala yang terbentuk pada konsentransi 20% yaitu sebesar 10,45 mm, pada konsentrasi 40% yaitu sebesar 11,4 mm, pada konsentrasi 60% yaitu sebesar 11,9 mm, pada konsentrasi 80% yaitu sebesar 12,35 mm, dan pada konsentrasi 100% yaitu sebesar 12,6 mm. Konsentrasi 100% mampu menghambat Staphylococcus epidermidis dengan rata-rata diameter zona hambat paling luas yaitu sebesar 12,6 mm.
{"title":"UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis","authors":"Marcelina Wandan Wisdyafanny, Yusianti Silviani","doi":"10.37013/jf.v12i1.221","DOIUrl":"https://doi.org/10.37013/jf.v12i1.221","url":null,"abstract":"Acne vulgaris atau jerawat dapat disebabkan oleh bakteri, salah satunya Staphylococcus epidermidis yang akan menghasilkan enzim lipolitik yang mengubah sebum menjadi massa padat, kemudian akan menyumbat saluran kelenjar sebasea. Daun pala mengandung senyawa saponin, triterpenoid, tanin, dan flavonoid sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui daya hambat ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap pertumbuhan Staphylococcus epidermidis. Penelitian ini menggunakan metode penelitian deskriptif eksperimental untuk mengetahui efektivitas antibakteri ekstrak etanol daun pala (Myristica fragrans Houtt) terhadap Staphylococcus epidermidis. Sumber data penelitian ini adalah data primer yaitu berdasarkan hasil zona hambat terhadap Staphylococcus epidermidis dengan pemberian ekstrak etanol daun pala (Myristica fragrans Houtt) dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun pala dapat digunakan sebagai antibakteri terhadap Staphylococcus epidermidis. Rata-rata diameter zona hambat ekstrak daun pala yang terbentuk pada konsentransi 20% yaitu sebesar 10,45 mm, pada konsentrasi 40% yaitu sebesar 11,4 mm, pada konsentrasi 60% yaitu sebesar 11,9 mm, pada konsentrasi 80% yaitu sebesar 12,35 mm, dan pada konsentrasi 100% yaitu sebesar 12,6 mm. Konsentrasi 100% mampu menghambat Staphylococcus epidermidis dengan rata-rata diameter zona hambat paling luas yaitu sebesar 12,6 mm.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
aseptic dispensing, reconstitution and storage of antibiotic injection
抗生素注射剂的无菌配制、重组和贮存
{"title":"Evaluation of Aseptic Actions of Pharmaceutical Technical Staff in the Process of Reconstitution and Storage of Antibiotic Injection in the Inpatient Room of UNS Hospital","authors":"Eka Rahma Noviyanti, Lusia Murtisiwi","doi":"10.37013/jf.v11i1.182","DOIUrl":"https://doi.org/10.37013/jf.v11i1.182","url":null,"abstract":"aseptic dispensing, reconstitution and storage of antibiotic injection","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91547347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jackfruit leaf extract was developed into a lotion preparation to increase skin moisture and prevent the skin from being exposed to free radicals. The purpose of this study was to determine the effect of variations in stearic acid base on physical quality, differences in antioxidant activity in jackfruit leaf extract and preparations, best formula that can provide antioxidant activity.Jackfruit leaf extract was obtained by maceration using 70% ethanol and then formulated with a concentration of 6% jackfruit leaf extract and variations in stearic acid base 2%, 3%, and 4%. This study used the DPPH method to determine antioxidant activity and ANOVA for statistical analysis. This study obtained the IC50 value of jackfruit leaf extract of 64.5616 ppm. Variations of stearic acid have an effect on the physical quality and value of antioxidant activity. The IC50 value of jackfruit leaf extract and lotion was different due to the presence of additional ingredients in the lotion. The best formula from this research, formula has the best physical quality value, with the IC50 value of the extract in the formula 70.6862 ppm and the IC50 value of the base in the formula 1179.3357 ppm.
{"title":"Pengaruh Konsentrasi Asam Stearat Terhadap Mutu Fisik Losion Ekstrak Daun Nangka (Arthocarpus heterophyllus) Sebagai Antioksidan","authors":"Natasya Sava Agasta, Siti Aisiyah, M. Rahayu","doi":"10.37013/jf.v11i1.173","DOIUrl":"https://doi.org/10.37013/jf.v11i1.173","url":null,"abstract":"Jackfruit leaf extract was developed into a lotion preparation to increase skin moisture and prevent the skin from being exposed to free radicals. The purpose of this study was to determine the effect of variations in stearic acid base on physical quality, differences in antioxidant activity in jackfruit leaf extract and preparations, best formula that can provide antioxidant activity.Jackfruit leaf extract was obtained by maceration using 70% ethanol and then formulated with a concentration of 6% jackfruit leaf extract and variations in stearic acid base 2%, 3%, and 4%. This study used the DPPH method to determine antioxidant activity and ANOVA for statistical analysis. This study obtained the IC50 value of jackfruit leaf extract of 64.5616 ppm. Variations of stearic acid have an effect on the physical quality and value of antioxidant activity. The IC50 value of jackfruit leaf extract and lotion was different due to the presence of additional ingredients in the lotion. The best formula from this research, formula has the best physical quality value, with the IC50 value of the extract in the formula 70.6862 ppm and the IC50 value of the base in the formula 1179.3357 ppm. ","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75176817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Mutiara, Achmad Wildan, Yustisia Dian Advistasari, Erwin Indriyanti
Derivat asam sinamat memainkan peran yang sangat penting dalam sintesis senyawa-senyawa penting lainnya dan sebagai prekursor untuk sintesis ester sinamat. Ester sinamat memiliki bioaktivitas yang beragam. Golongan ini memiliki aktivitas antioksidan, hepatoprotektif, antiinflamasi, anxiolitik, penolak serangga, antidiabetik dan antikolesterol. Oktilsinamat merupakan derivat asam sinamat diduga berkhasiat sebagai penurun kadar kolesterol. Kolesterol telah dikenal sebagai penyebab utama terjadinya proses aterosklerosis, yaitu proses pengapuran dan pengerasan pembuluh darah. Akibat proses ini saluran pembuluh darah, khususnya pembuluh darah koroner menjadi sempit dan menghalangi aliran darah.. Oktilsinamat telah berhasil disintesis dari reaksi esterifikasi antara asam sinamat dan n-oktanol dengan katalis asam sulfat pekat. Metode sonokimia merupakan salah satu metode yang dikembangkan dalam proses sintesis ini karena sangat mudah dilakukan, efisien, dengan rendemen yang tinggi, waktu yang singkat dan ramah lingkungan. Dari hasil sintesis dilakukan identifikasi senyawa melalui titik leleh dan spektrofotometri FTIR. Berdasarkan hasil interpretasi data dari FTIR bahwa hasil sintesis adalah n-oktil sinamat.Sintesis dilakukan padai suhu 600C dengan lama waktu sonikasi 7 jam. Aktivitas antikolesterol dari senyawa n-oktil sinamat hasil sintesis yang optimal pada konsentrasi 5 ppm adalah sebesar 55,42%.
{"title":"SINTESIS OKTIL SINAMAT DENGAN METODE SONOKIMIA DAN POTENSINYA SEBAGAI ANTIKOLESTEROL","authors":"E. Mutiara, Achmad Wildan, Yustisia Dian Advistasari, Erwin Indriyanti","doi":"10.37013/jf.v11i1.178","DOIUrl":"https://doi.org/10.37013/jf.v11i1.178","url":null,"abstract":"Derivat asam sinamat memainkan peran yang sangat penting dalam sintesis senyawa-senyawa penting lainnya dan sebagai prekursor untuk sintesis ester sinamat. Ester sinamat memiliki bioaktivitas yang beragam. Golongan ini memiliki aktivitas antioksidan, hepatoprotektif, antiinflamasi, anxiolitik, penolak serangga, antidiabetik dan antikolesterol. Oktilsinamat merupakan derivat asam sinamat diduga berkhasiat sebagai penurun kadar kolesterol. Kolesterol telah dikenal sebagai penyebab utama terjadinya proses aterosklerosis, yaitu proses pengapuran dan pengerasan pembuluh darah. Akibat proses ini saluran pembuluh darah, khususnya pembuluh darah koroner menjadi sempit dan menghalangi aliran darah.. Oktilsinamat telah berhasil disintesis dari reaksi esterifikasi antara asam sinamat dan n-oktanol dengan katalis asam sulfat pekat. Metode sonokimia merupakan salah satu metode yang dikembangkan dalam proses sintesis ini karena sangat mudah dilakukan, efisien, dengan rendemen yang tinggi, waktu yang singkat dan ramah lingkungan. Dari hasil sintesis dilakukan identifikasi senyawa melalui titik leleh dan spektrofotometri FTIR. Berdasarkan hasil interpretasi data dari FTIR bahwa hasil sintesis adalah n-oktil sinamat.Sintesis dilakukan padai suhu 600C dengan lama waktu sonikasi 7 jam. Aktivitas antikolesterol dari senyawa n-oktil sinamat hasil sintesis yang optimal pada konsentrasi 5 ppm adalah sebesar 55,42%.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88262577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recycling technology processes used cooking oil into reusable oil using bagasse as an absorbent material, to determinate the decrease in water content in used cooking oil using bagasse chacoal. the reseach method is experimental. The sample used is used cooking oil. Water level before the addition of bagasse charcoal was 0,3%. This results after the additional of bagasse charchoal with variation of immersion time 1x24 hours, 2x24 hours and 3x24 hours was 0,1%, 0,03%, and 0,02%.There is reducing in water level after soaking using bagasse charcoal. Water level from used cooking oil more smaller after the addition of soaking time by bagasse charcoal.
{"title":"The Reduction Of Water Level In Used Cooking Oil Using Bagasse Charcoal (Saccharum officinarum)","authors":"Kharisma Islamia Nanda Giovani, Purwati Purwati","doi":"10.37013/jf.v11i1.168","DOIUrl":"https://doi.org/10.37013/jf.v11i1.168","url":null,"abstract":"Recycling technology processes used cooking oil into reusable oil using bagasse as an absorbent material, to determinate the decrease in water content in used cooking oil using bagasse chacoal. the reseach method is experimental. The sample used is used cooking oil. Water level before the addition of bagasse charcoal was 0,3%. This results after the additional of bagasse charchoal with variation of immersion time 1x24 hours, 2x24 hours and 3x24 hours was 0,1%, 0,03%, and 0,02%.There is reducing in water level after soaking using bagasse charcoal. Water level from used cooking oil more smaller after the addition of soaking time by bagasse charcoal.","PeriodicalId":17954,"journal":{"name":"Jurnal Farmasi (Journal of Pharmacy)","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81377987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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