脑型疟疾中的血小板和微粒:不寻常的嫌疑人

Drug discovery today. Disease mechanisms Pub Date : 2011-06-01 DOI:10.1016/j.ddmec.2011.11.004

Samuel C. Wassmer , Valéry Combes , Georges E.R. Grau

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引用次数: 23

摘要

血小板和微粒可能在脑型疟疾的发病过程中发挥关键作用，它们协助受感染的红细胞与脑血管系统结合，并介导许多炎症和免疫过程。本综述汇编了它们与微血管内皮、受感染红细胞和免疫细胞相互作用的最新发现，这些相互作用可能影响脑疟疾的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Platelets and microparticles in cerebral malaria: the unusual suspects

Platelets and microparticles might have a crucial role in the pathogenesis of cerebral malaria by assisting in the binding of infected erythrocytes to the cerebral vasculature and mediating numerous inflammatory and immune processes. The present review compiles a selection of the recent findings on their interactions with microvascular endothelium, infected erythrocytes and immune cells that may influence the development of cerebral malaria.

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Drug discovery today. Disease mechanisms

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