Photosensitizer accumulation in the bladder mucosa in chronic cystitis

Purpose . To study the accumulation of photosensitizer Photoditazine in the bladder mucous in chronic cystitis. Material and methods . 22 patients with chronic cystitis were taken into the study. The time of Photoditazine accumulation in the bladder mucous was determined with a multi-channel optical fiber spectroanalyzer («LESA-01-BIOSPEC»). Photodynamic therapy (PDT) was done with laser «ATKUS-2» having adjustable output power up to 2 W and wavelength 661 ± 0.03 nm. Results . The performed fluorescence spectroscopy has revealed that the maximal accumulation time of Photoditazine in the bladder mucous in chronic cystitis is 120–150 minutes. After laser exposure, by spectroscopy finings, fluorescence intensity decreases by 72.3% which indicates a pronounced photosensitizer excitation and an active photodynamic reaction. Conclusion . The optimal time for laser photodynamic therapy in chronic cystitis is 2–2.5 hours after photosensitizer injection. Spectroscopy findings after laser exposure demonstrate the effectiveness of photodynamic therapy in chronic cystitis.