{"title":"卡格列净:生物基质和药物的分析方法综述","authors":"Ajitha Azhakesan, Sujatha Kuppusamy","doi":"10.1515/revac-2022-0049","DOIUrl":null,"url":null,"abstract":"Abstract Sodium-glucose transporter 2 inhibitor emerges as the latest group of oral hypoglycemic agents, which shows insulin-independent pathology and provides an upper hand to enhance renal glucose elimination. Canagliflozin (CGN) was the number one drug, approved by FDA on 29th March 2013 for the treatment of type 2 diabetes mellitus. By totting up to its glucose-lowering effects, it exhibits beneficial effects on the heart and potentially on the kidneys. The study aims to summarize various analytical techniques, such as chromatography, spectrophotometry, and hyphenated techniques, such as Liquid chromatography with tandem mass spectrometry (LC-MS/MS) and Ultra performance liquid chromatography with tandem mass spectrometer (UPLC-MS) for the analysis of CGN. In the proposed work, we have reviewed various analytical methods reported for the estimation of CGN in biological matrices and Pharmaceuticals from various databases like ScienceDirect, Springer, PubMed, Scopus, Taylor & Francis, and Web of Science for the estimation of CGN. Various analytical methods adapted were high-performance liquid chromatography, UPLC, LC-MS/MS, high-performance thin-layer liquid chromatography, Fourier-transform infrared spectroscopy, spectrofluorimetry, and UV spectrophotometry. This current review presented the determination of CGN using various analytical techniques and biological matrices either in single or in combination with other hypoglycemic agents, as per International Conference on Harmonization guidelines. 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引用次数: 1
摘要
钠-葡萄糖转运蛋白2抑制剂是最新出现的一类口服降糖药,具有胰岛素不依赖型病理,在促进肾脏葡萄糖消除方面具有优势。Canagliflozin (CGN)是2013年3月29日获FDA批准用于治疗2型糖尿病的头号药物。总的来说,它的降糖作用对心脏和肾脏都有好处。本研究旨在总结各种分析技术,如色谱法、分光光度法和联用技术,如液相色谱-串联质谱法(LC-MS/MS)和超高效液相色谱-串联质谱法(UPLC-MS),用于分析CGN。在本文中,我们回顾了来自ScienceDirect、b施普林格、PubMed、Scopus、Taylor & Francis和Web of Science等不同数据库中用于估算生物基质和药物中CGN的各种分析方法。采用的分析方法有高效液相色谱法、UPLC法、LC-MS/MS法、高效薄层液相色谱法、傅里叶变换红外光谱法、荧光光谱法、紫外分光光度法等。根据国际协调会议的指导方针,本综述介绍了使用各种分析技术和生物基质单独或与其他降糖药联合测定CGN的方法。此外,还提出了一些可以综合的未来趋势。
Canagliflozin: A review with specific focus on analytical methods in biological matrices and pharmaceuticals
Abstract Sodium-glucose transporter 2 inhibitor emerges as the latest group of oral hypoglycemic agents, which shows insulin-independent pathology and provides an upper hand to enhance renal glucose elimination. Canagliflozin (CGN) was the number one drug, approved by FDA on 29th March 2013 for the treatment of type 2 diabetes mellitus. By totting up to its glucose-lowering effects, it exhibits beneficial effects on the heart and potentially on the kidneys. The study aims to summarize various analytical techniques, such as chromatography, spectrophotometry, and hyphenated techniques, such as Liquid chromatography with tandem mass spectrometry (LC-MS/MS) and Ultra performance liquid chromatography with tandem mass spectrometer (UPLC-MS) for the analysis of CGN. In the proposed work, we have reviewed various analytical methods reported for the estimation of CGN in biological matrices and Pharmaceuticals from various databases like ScienceDirect, Springer, PubMed, Scopus, Taylor & Francis, and Web of Science for the estimation of CGN. Various analytical methods adapted were high-performance liquid chromatography, UPLC, LC-MS/MS, high-performance thin-layer liquid chromatography, Fourier-transform infrared spectroscopy, spectrofluorimetry, and UV spectrophotometry. This current review presented the determination of CGN using various analytical techniques and biological matrices either in single or in combination with other hypoglycemic agents, as per International Conference on Harmonization guidelines. Further, some future trends that can be integrated were also suggested.
期刊介绍:
Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.