Glyceryl monostearate based nanoparticles of mefenamic acid: Fabrication and in vitro characterization

Objective

The aim of present research work was to fabricate and evaluate the Mefenamic acid (MF) loaded Solid lipid nanoparticles (SLNs) using Glyceryl monostearate as lipid and tween 80 as surfactant.

Method

MF loaded SLNs were prepared by Solvent Emulsification diffusion technique. Various batches were prepared by hit and trial method varying drug to lipid ratio and surfactant concentration and evaluated for particle size & distribution, particle morphology, zeta potential, percent drug loading and percent drug entrapment efficiency.

Result

Among various lipids like Glyceryl monostearate, Stearic acid and Palmitic acid, GMS was selected for the fabrication of SLNs it was due to the highest solubility of MF in GMS as compared to other above mentioned lipids. Particle size, polydispersity index (PDI), zeta potential, percent drug loading and percent drug entrapment efficiency were found to be 109.7 nm, 0.34, −20.3 mV, 43.00 and 75.45 respectively. Morphologically the SLNs were found to be spherical with rough surfaces. The optimized formulation exhibited 93.28% cumulative drug release after 24 h, while the release mechanism was found to be Fickian diffusion type.

Conclusion

It is concluded that Solvent Emulsification diffusion technique is suitable for fabrication of MF loaded SLNs. All evaluating parameters of optimized SLNs were found to be in acceptable range.