Lemus-Varela Ml, García-Valdez Lm, R. R, Zúñiga-González Gm, G. Mp
{"title":"SOD2 Rs5746136 C>T多态性与新生儿持续性肺动脉高压风险的关系","authors":"Lemus-Varela Ml, García-Valdez Lm, R. R, Zúñiga-González Gm, G. Mp","doi":"10.33425/2689-1085.1022","DOIUrl":null,"url":null,"abstract":"Background: Persistent pulmonary hypertension of a newborn (PPHN) is a serious condition with a high morbidity and mortality rate, with a complex therapeutic approach. Recently, genetic associations have been found in patients with PPHN, the role of some polymorphisms that explain its pathogenesis has not been well defined. Objective: To determine the frequency of association of SOD2 gene polymorphisms (rs5746136 C>T) in PPHN in the Mexican population. Methods: We included 155 Mexican infants; 76 with PPHN, confirmed by echocardiography (study group), and 79 healthy newborns (control group) and by polymerase chain reaction (PCR) and RFLPs was identified the rs5746136 polymorphism in SOD2 gene. Results: The group with PPHN had a lower gestational age (35.6 ± 2.81 weeks versus 38.1 ± 1.9; P=0.008) and a lower mean body weight (2,622 ± 626 g versus 2,992 ± 565 g, P=0.052) than the controls respectively. The rs5746136 C>T polymorphism was associated with PPHN susceptibility, when PPHN patients and the control group were compared for the TT genotype (OR 8.1, 95%CI 2.65-24.9; P=0.0001), the CT/TT genotype (OR 6.5, 95% CI 3.12-13.5; P=0.0001), and the T allele (OR 4.3, 95% CI 2.63-7.02; P=0.0001). Conclusion: We found significant differences in the association of rs5746136 C>T polymorphism of SOD2 gene in PPHN of the Mexican population analyzed.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Association of the SOD2 Rs5746136 C>T Polymorphisms with The Risk of Persistent Pulmonary Hypertension of The Newborn\",\"authors\":\"Lemus-Varela Ml, García-Valdez Lm, R. R, Zúñiga-González Gm, G. Mp\",\"doi\":\"10.33425/2689-1085.1022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Persistent pulmonary hypertension of a newborn (PPHN) is a serious condition with a high morbidity and mortality rate, with a complex therapeutic approach. Recently, genetic associations have been found in patients with PPHN, the role of some polymorphisms that explain its pathogenesis has not been well defined. Objective: To determine the frequency of association of SOD2 gene polymorphisms (rs5746136 C>T) in PPHN in the Mexican population. Methods: We included 155 Mexican infants; 76 with PPHN, confirmed by echocardiography (study group), and 79 healthy newborns (control group) and by polymerase chain reaction (PCR) and RFLPs was identified the rs5746136 polymorphism in SOD2 gene. Results: The group with PPHN had a lower gestational age (35.6 ± 2.81 weeks versus 38.1 ± 1.9; P=0.008) and a lower mean body weight (2,622 ± 626 g versus 2,992 ± 565 g, P=0.052) than the controls respectively. The rs5746136 C>T polymorphism was associated with PPHN susceptibility, when PPHN patients and the control group were compared for the TT genotype (OR 8.1, 95%CI 2.65-24.9; P=0.0001), the CT/TT genotype (OR 6.5, 95% CI 3.12-13.5; P=0.0001), and the T allele (OR 4.3, 95% CI 2.63-7.02; P=0.0001). Conclusion: We found significant differences in the association of rs5746136 C>T polymorphism of SOD2 gene in PPHN of the Mexican population analyzed.\",\"PeriodicalId\":75037,\"journal\":{\"name\":\"The Internet journal of pediatrics and neonatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet journal of pediatrics and neonatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33425/2689-1085.1022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet journal of pediatrics and neonatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33425/2689-1085.1022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association of the SOD2 Rs5746136 C>T Polymorphisms with The Risk of Persistent Pulmonary Hypertension of The Newborn
Background: Persistent pulmonary hypertension of a newborn (PPHN) is a serious condition with a high morbidity and mortality rate, with a complex therapeutic approach. Recently, genetic associations have been found in patients with PPHN, the role of some polymorphisms that explain its pathogenesis has not been well defined. Objective: To determine the frequency of association of SOD2 gene polymorphisms (rs5746136 C>T) in PPHN in the Mexican population. Methods: We included 155 Mexican infants; 76 with PPHN, confirmed by echocardiography (study group), and 79 healthy newborns (control group) and by polymerase chain reaction (PCR) and RFLPs was identified the rs5746136 polymorphism in SOD2 gene. Results: The group with PPHN had a lower gestational age (35.6 ± 2.81 weeks versus 38.1 ± 1.9; P=0.008) and a lower mean body weight (2,622 ± 626 g versus 2,992 ± 565 g, P=0.052) than the controls respectively. The rs5746136 C>T polymorphism was associated with PPHN susceptibility, when PPHN patients and the control group were compared for the TT genotype (OR 8.1, 95%CI 2.65-24.9; P=0.0001), the CT/TT genotype (OR 6.5, 95% CI 3.12-13.5; P=0.0001), and the T allele (OR 4.3, 95% CI 2.63-7.02; P=0.0001). Conclusion: We found significant differences in the association of rs5746136 C>T polymorphism of SOD2 gene in PPHN of the Mexican population analyzed.