Objective: To evaluate the incidence of Developmental Hip Dysplasia (DDH) in preterm breech infants at our institution and screening practices among providers that manage DDH in the preterm population. Design: We reviewed charts of infants born in a single quaternary care urban medical center between 2012-2022. Infants born <37 weeks Gestation Age (GA) with breech presentation and screening ultrasonography done within the system were included. Infants with genetic syndromes were excluded. Data were extracted using Epic Slicer/Dicer and collected using RedCAP. A survey assessing provider screening practices concerning DDH in preterm infants was sent to pediatricians, neonatologists, and orthopedists. Results: Two thousand seven hundred ninety six charts were reviewed, and 147 met the inclusion criteria. An overall incidence of DDH was found to be 6.1% (9/147), with 5.6% (1/18) in <32 weeks GA infants and 6.2% (8/129) in 32-37 weeks GA infants. Screening before 40 weeks of corrected GA was performed in 34.7% (51/147) of all infants and in 66.7% (6/9) of infants with DDH. 234 physicians responded to the survey. A large majority of each group believed this population should be screened. While most think both preterm and late preterm breech infants should be screened at 6 weeks corrected age, survey results showed discordance among current screening practices. Conclusion: The incidence of DDH in preterm breech infants is lower than the reported incidence in the term breech population, and clinicians should consider this before ultrasound screening. Additionally, variation exists in provider practices for screening preterm breech infants suggesting a need for updated clinical guidelines.
{"title":"Incidence and Screening Practices of Developmental Hip Dysplasia in Preterm Breech Infants","authors":"Zachary Henig, Alyssa Khoo, Cole Turner, Kashif Iqubal, Kristyn Pierce, Pablo Castaneda, Erin Hanft","doi":"10.33597/2688-5573-v4-id1035","DOIUrl":"https://doi.org/10.33597/2688-5573-v4-id1035","url":null,"abstract":"Objective: To evaluate the incidence of Developmental Hip Dysplasia (DDH) in preterm breech infants at our institution and screening practices among providers that manage DDH in the preterm population. Design: We reviewed charts of infants born in a single quaternary care urban medical center between 2012-2022. Infants born <37 weeks Gestation Age (GA) with breech presentation and screening ultrasonography done within the system were included. Infants with genetic syndromes were excluded. Data were extracted using Epic Slicer/Dicer and collected using RedCAP. A survey assessing provider screening practices concerning DDH in preterm infants was sent to pediatricians, neonatologists, and orthopedists. Results: Two thousand seven hundred ninety six charts were reviewed, and 147 met the inclusion criteria. An overall incidence of DDH was found to be 6.1% (9/147), with 5.6% (1/18) in <32 weeks GA infants and 6.2% (8/129) in 32-37 weeks GA infants. Screening before 40 weeks of corrected GA was performed in 34.7% (51/147) of all infants and in 66.7% (6/9) of infants with DDH. 234 physicians responded to the survey. A large majority of each group believed this population should be screened. While most think both preterm and late preterm breech infants should be screened at 6 weeks corrected age, survey results showed discordance among current screening practices. Conclusion: The incidence of DDH in preterm breech infants is lower than the reported incidence in the term breech population, and clinicians should consider this before ultrasound screening. Additionally, variation exists in provider practices for screening preterm breech infants suggesting a need for updated clinical guidelines.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135497544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.33597/2688-5573-v4-id1029
Harsh Prabha Soni, P. Beck, Sharja Phuljhele
Introduction: LBW is known to be associated with subsequent health issues such as poor anthropometric growth in childhood. Late catch-up growth of preterm infants throughout childhood linked to an adverse health outcome. The aim of this study is to study the growth parameters of healthy low birth weight neonates discharged from post-natal ward. Material and methods: This was a hospital based prospective cross-sectional study conducted in year of 2022 in the department of pediatrics at Pt JNMCH, Raipur. Vitally stable LBW neonates were recruited in the study. The sample size calculated was 140. At the time of birth anthropometric measurement i.e. head circumference, length, weight was taken. Follow up was done again at 1.5 month, 2.5 month and 3.5 month. Informed consent was taken form care takers prior to inclusion in the study. Results: In present study 140 newborns were followed up for their growth. The mean difference between birth weight at birth and at 1.5 months was 1.150 kg (p<0.01), at 1.5 months and weight at 2.5 months was 1.129 kg (p<0.01) and at 2.5 months and weight at 3.5 months was 1.436 kg (p<0.01). Type of feed wise mean weight gain at 1.5 months was highest on those on formula feed, mother milk and those on mixed feed. Male had higher mean weight gain than female. Conclusion: The present study concluded that postnatal lactation counseling leads to higher weight gain in infants as compared to those on formula feed.
简介:众所周知，低体重与随后的健康问题有关，如儿童时期人体测量生长不良。早产儿在整个儿童期的后起之长与不利的健康结果有关。本研究的目的是研究出生后出院的健康低出生体重新生儿的生长参数。材料和方法:这是一项基于医院的前瞻性横断面研究，于2022年在rapur的Pt JNMCH儿科进行。研究招募了生命稳定的低体重新生儿。计算的样本量为140。在出生时进行人体测量，即头围、身长、体重。随访时间分别为1.5个月、2.5个月和3.5个月。在纳入研究之前，从照顾者那里获得了知情同意。结果:本研究对140例新生儿的生长情况进行了随访。出生时体重与1.5月龄的平均差值为1.150 kg (p<0.01)， 1.5月龄与2.5月龄的平均差值为1.129 kg (p<0.01)， 2.5月龄与3.5月龄的平均差值为1.436 kg (p<0.01)。在饲料种类方面，1.5个月时平均增重最高的是配方饲料、母乳和混合饲料。男性的平均体重增加高于女性。结论:目前的研究得出结论，产后哺乳咨询导致婴儿体重增加比那些配方饲料。
{"title":"Growth Parameters and Follow up of Low-Birth-Weight Healthy Newborn Discharged from Post Natal Ward of Dr. BRAMH Raipur till 4 Month of Age","authors":"Harsh Prabha Soni, P. Beck, Sharja Phuljhele","doi":"10.33597/2688-5573-v4-id1029","DOIUrl":"https://doi.org/10.33597/2688-5573-v4-id1029","url":null,"abstract":"Introduction: LBW is known to be associated with subsequent health issues such as poor anthropometric growth in childhood. Late catch-up growth of preterm infants throughout childhood linked to an adverse health outcome. The aim of this study is to study the growth parameters of healthy low birth weight neonates discharged from post-natal ward. Material and methods: This was a hospital based prospective cross-sectional study conducted in year of 2022 in the department of pediatrics at Pt JNMCH, Raipur. Vitally stable LBW neonates were recruited in the study. The sample size calculated was 140. At the time of birth anthropometric measurement i.e. head circumference, length, weight was taken. Follow up was done again at 1.5 month, 2.5 month and 3.5 month. Informed consent was taken form care takers prior to inclusion in the study. Results: In present study 140 newborns were followed up for their growth. The mean difference between birth weight at birth and at 1.5 months was 1.150 kg (p<0.01), at 1.5 months and weight at 2.5 months was 1.129 kg (p<0.01) and at 2.5 months and weight at 3.5 months was 1.436 kg (p<0.01). Type of feed wise mean weight gain at 1.5 months was highest on those on formula feed, mother milk and those on mixed feed. Male had higher mean weight gain than female. Conclusion: The present study concluded that postnatal lactation counseling leads to higher weight gain in infants as compared to those on formula feed.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85165026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Accurate childhood cancer burden data are crucial for resource planning and health policy prioritization. In Bangladesh we have no national population based cancer registry. Data about the total burden of childhood cancer in our country is unknown. But a hospital based cancer registry is the cheapest way to assess the tumor burden of a nation. So we investigate the total pediatric cancer burden and the percentage of different types of rare childhood cancers (RCC) of National Institute of Cancer Research and Hospital (NICRH), Dhaka, during the year 2014 – 2018. Aim: To investigate the total number of pediatric cancers, frequency of different types of rare cancer and percentage of rare childhood cancer in the Pediatric Hematology and Oncology (PHO) department. Methods: Data were collected from all pediatric (0-17 years) patients between the year 2014 and 2018 prospectively. Definitive diagnosis of cases were established by histopathological and or immunohistochemical study. As we have no population-based cancer registry, we considered the rare tumors in our study according to the Children's Oncology Group (COG) and the German Childhood Cancer Registry (GCCR). Results: Total number of childhood cancers and RCC was 2242 and 351 respectively. Percentage of rare tumors was 15.66% in our center. Benign rare tumors were 18.52% (N-65) cases. Common age group was the 5-9 years group (54.13 %). Most common RCC groups were Non-Rhabdomyosarcoma soft tissue sarcoma (NRSTS) constituting 49.29 %, followed by Malignant epithelial neoplasms and melanomas (38.18%). Diagnostic delay was 3.52 months. Most common malignancy was Synovial Sarcoma (N-40, 11.39%), Peripheral Neuroectodermal Tumor (N-39, 11.11%), Nasopharyngeal carcinoma (N-35, 9.97%), Malignant small round cell tumor (N-31, 8.83%) and Carcinoma rectum and colon (N-23, 6.55%). Conclusion: We have found that our Institutional (NICRH) rare tumor rate (15.66%) was a bit higher than US national RCC (15%). Though Institutional cancer data reflect the national burden, to estimate the accurate number and percentage of RCC, National Cancer Registry is needed.
{"title":"Rare Childhood Cancer Burden in a Tertiary Care Hospital of Dhaka, Bangladesh","authors":"Ghosh Ak, Diba F, V. T.","doi":"10.33425/2689-1085.1032","DOIUrl":"https://doi.org/10.33425/2689-1085.1032","url":null,"abstract":"Background: Accurate childhood cancer burden data are crucial for resource planning and health policy prioritization. In Bangladesh we have no national population based cancer registry. Data about the total burden of childhood cancer in our country is unknown. But a hospital based cancer registry is the cheapest way to assess the tumor burden of a nation. So we investigate the total pediatric cancer burden and the percentage of different types of rare childhood cancers (RCC) of National Institute of Cancer Research and Hospital (NICRH), Dhaka, during the year 2014 – 2018. Aim: To investigate the total number of pediatric cancers, frequency of different types of rare cancer and percentage of rare childhood cancer in the Pediatric Hematology and Oncology (PHO) department. Methods: Data were collected from all pediatric (0-17 years) patients between the year 2014 and 2018 prospectively. Definitive diagnosis of cases were established by histopathological and or immunohistochemical study. As we have no population-based cancer registry, we considered the rare tumors in our study according to the Children's Oncology Group (COG) and the German Childhood Cancer Registry (GCCR). Results: Total number of childhood cancers and RCC was 2242 and 351 respectively. Percentage of rare tumors was 15.66% in our center. Benign rare tumors were 18.52% (N-65) cases. Common age group was the 5-9 years group (54.13 %). Most common RCC groups were Non-Rhabdomyosarcoma soft tissue sarcoma (NRSTS) constituting 49.29 %, followed by Malignant epithelial neoplasms and melanomas (38.18%). Diagnostic delay was 3.52 months. Most common malignancy was Synovial Sarcoma (N-40, 11.39%), Peripheral Neuroectodermal Tumor (N-39, 11.11%), Nasopharyngeal carcinoma (N-35, 9.97%), Malignant small round cell tumor (N-31, 8.83%) and Carcinoma rectum and colon (N-23, 6.55%). Conclusion: We have found that our Institutional (NICRH) rare tumor rate (15.66%) was a bit higher than US national RCC (15%). Though Institutional cancer data reflect the national burden, to estimate the accurate number and percentage of RCC, National Cancer Registry is needed.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73962672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Patricia Vargas Sanabria, María Azucena Niño Tovar, Ariana Liseth Acosta Rodriguez, Angie Lorena Acosta Rodriguez, L. Pérez
Introduction: Prematurity causes great morbidity and mortality in childhood, which is why the identification and prevention of risk factors is essential. Objective: To identify the association of non-infectious risk factors with prematurity in two reference centers in northeastern Colombia. Patients and Methods: Multicenter prospective cohort study carried out between January 2019 and March 2020. A non-probabilistic convenience sampling was carried out in pregnant women with a single pregnancy, greater than 20 weeks who were then followed up monthly until the moment of birth. Preterm birth was considered as an outcome variable, after the normality analysis, based on Shapiro-Wilk Test; Chi2 or Fisher tests were performed for qualitative variables, and t-test or Wilcoxon test for quantitative variables, p <0.05 was considered significant and OR was calculated by regression logistics. Results: 559 pregnant women were studied, with 63 preterm births. An association was found between prematurity and gestational obesity (OR 2.71; 95% CI 1.52-4.81), hypertensive disorder associated with pregnancy (OR 3.88; 95% CI 2.18-6.90), premature rupture of membranes (OR 3.86 95% CI 1.60-9.29) and previous preterm labor in the current pregnancy (OR 17.39 95% CI 9.57-31.51). Conclusions: Prematurity is significantly associated with gestational obesity, pregnancy-associated hypertensive disorder, premature rupture of membranes, and previous preterm labor in current pregnancy. Further studies would be needed to support these findings.
前言:早产导致儿童发病率和死亡率很高，因此确定和预防危险因素至关重要。目的:确定哥伦比亚东北部两个参考中心非传染性危险因素与早产的关系。患者和方法:2019年1月至2020年3月进行的多中心前瞻性队列研究。对单次怀孕超过20周的孕妇进行了非概率方便抽样，然后每个月对她们进行随访，直到分娩。根据夏皮罗-威尔克检验进行正态性分析后，早产被认为是一个结局变量;定性变量采用Chi2或Fisher检验，定量变量采用t检验或Wilcoxon检验，p <0.05为显著性，采用回归逻辑计算or。结果:559名孕妇被调查，其中63名早产。早产与妊娠期肥胖之间存在关联(OR 2.71;95% CI 1.52-4.81)，高血压疾病与妊娠相关(OR 3.88;(95% CI 2.18-6.90)，胎膜早破(OR 3.86 95% CI 1.60-9.29)和当前妊娠的早产(OR 17.39 95% CI 9.57-31.51)。结论:早产与妊娠期肥胖、妊娠相关性高血压疾病、胎膜早破和妊娠期早产显著相关。需要进一步的研究来支持这些发现。
{"title":"Risk Factors Associated with Prematurity Other than Infectious Causes: A Prospective Multicenter Cohort Study in the Colombian Northeast","authors":"Andrea Patricia Vargas Sanabria, María Azucena Niño Tovar, Ariana Liseth Acosta Rodriguez, Angie Lorena Acosta Rodriguez, L. Pérez","doi":"10.33425/2689-1085.1031","DOIUrl":"https://doi.org/10.33425/2689-1085.1031","url":null,"abstract":"Introduction: Prematurity causes great morbidity and mortality in childhood, which is why the identification and prevention of risk factors is essential. Objective: To identify the association of non-infectious risk factors with prematurity in two reference centers in northeastern Colombia. Patients and Methods: Multicenter prospective cohort study carried out between January 2019 and March 2020. A non-probabilistic convenience sampling was carried out in pregnant women with a single pregnancy, greater than 20 weeks who were then followed up monthly until the moment of birth. Preterm birth was considered as an outcome variable, after the normality analysis, based on Shapiro-Wilk Test; Chi2 or Fisher tests were performed for qualitative variables, and t-test or Wilcoxon test for quantitative variables, p <0.05 was considered significant and OR was calculated by regression logistics. Results: 559 pregnant women were studied, with 63 preterm births. An association was found between prematurity and gestational obesity (OR 2.71; 95% CI 1.52-4.81), hypertensive disorder associated with pregnancy (OR 3.88; 95% CI 2.18-6.90), premature rupture of membranes (OR 3.86 95% CI 1.60-9.29) and previous preterm labor in the current pregnancy (OR 17.39 95% CI 9.57-31.51). Conclusions: Prematurity is significantly associated with gestational obesity, pregnancy-associated hypertensive disorder, premature rupture of membranes, and previous preterm labor in current pregnancy. Further studies would be needed to support these findings.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"307 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77508509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kane, D. I., Gueye Ms, N. B, M. A, Diagne G, Coundoul A.M, Dieng Yj, Cissé Df, B. I, T. A, Fattah M, Bop K.B, S. S, Nakoulima A, D. A, Keita Y, Faye Pm, Fall Al, Sylla A, D. I, Dieye Tn, N. O
Background: Primary immunodeficiencies are a group of about 400 diseases of genetic origin, they are considered as rare diseases. However, above 6 million people in the world would be affected, regardless of sex, age or geographical area. Few studies have been conducted in sub-Saharan Africa. The main objective of this study was to show existence of these diseases in West Africa and difficulties to manage it. The specific objectives were to identify the different clinical patterns of PI cases, to describe their biological phenotypes and to propose management. Method: A cross-sectional observational study over a period of 4 years and 2 months resulted in recruitment of children with either 2 or more signs among the 10 warning signs for PID or with signs described in the 10 recommendations for diagnosis of PID from African Society for Immunodeficiencies (ASID). Biological and immunological exploration were carried out in these patients. The diagnostic approach of PID for emerging countries according to the method of B. Admou and et al. was adopted. Results: 30 cases of PID were recorded. The sex ratio was 1; with a median age at diagnosis of 24 months. The most common clinical symptoms were respiratory infections, followed by digestive and then cutaneous manifestations. 10 children had immunological confirmation. One patient had genetic confirmation of WAS. The most common category of PID was syndromic PID. Management was limited, based mainly on antibiotic prophylaxis. The death of 5 patients was recorded. Conclusion: PI are a severe condition and certainly underestimated in Senegal. This is due to the lack of knowledge of these diseases by physicians but also to an insufficient access to diagnostic tools. The raising of the technical platform will allow better documentation of these diseases, and advocate for access to certain treatments such as immunoglobulins supplementation and bone marrow transplantation.
{"title":"Primary Immunodeficiencies (Pi) in Senegalese Children: A Series of 30 Cases","authors":"A. Kane, D. I., Gueye Ms, N. B, M. A, Diagne G, Coundoul A.M, Dieng Yj, Cissé Df, B. I, T. A, Fattah M, Bop K.B, S. S, Nakoulima A, D. A, Keita Y, Faye Pm, Fall Al, Sylla A, D. I, Dieye Tn, N. O","doi":"10.33425/2689-1085.1029","DOIUrl":"https://doi.org/10.33425/2689-1085.1029","url":null,"abstract":"Background: Primary immunodeficiencies are a group of about 400 diseases of genetic origin, they are considered as rare diseases. However, above 6 million people in the world would be affected, regardless of sex, age or geographical area. Few studies have been conducted in sub-Saharan Africa. The main objective of this study was to show existence of these diseases in West Africa and difficulties to manage it. The specific objectives were to identify the different clinical patterns of PI cases, to describe their biological phenotypes and to propose management. Method: A cross-sectional observational study over a period of 4 years and 2 months resulted in recruitment of children with either 2 or more signs among the 10 warning signs for PID or with signs described in the 10 recommendations for diagnosis of PID from African Society for Immunodeficiencies (ASID). Biological and immunological exploration were carried out in these patients. The diagnostic approach of PID for emerging countries according to the method of B. Admou and et al. was adopted. Results: 30 cases of PID were recorded. The sex ratio was 1; with a median age at diagnosis of 24 months. The most common clinical symptoms were respiratory infections, followed by digestive and then cutaneous manifestations. 10 children had immunological confirmation. One patient had genetic confirmation of WAS. The most common category of PID was syndromic PID. Management was limited, based mainly on antibiotic prophylaxis. The death of 5 patients was recorded. Conclusion: PI are a severe condition and certainly underestimated in Senegal. This is due to the lack of knowledge of these diseases by physicians but also to an insufficient access to diagnostic tools. The raising of the technical platform will allow better documentation of these diseases, and advocate for access to certain treatments such as immunoglobulins supplementation and bone marrow transplantation.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79824798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
While discrete trial ABA programs remain the “go to” intervention for most young children with autism, they do not make inroads for all. This paper documents important clinical gains made by such a “treatment-resistant” older youngster with severe autism by means of a biologic/nutritional approach. The possibility is raised of using these approaches synergistically.
{"title":"Different Treatment Modalities Lead to Successful Starts for Two ASD Youngsters with High and Low Levels of Function","authors":"Dean Alexander","doi":"10.33425/2689-1085.1030","DOIUrl":"https://doi.org/10.33425/2689-1085.1030","url":null,"abstract":"While discrete trial ABA programs remain the “go to” intervention for most young children with autism, they do not make inroads for all. This paper documents important clinical gains made by such a “treatment-resistant” older youngster with severe autism by means of a biologic/nutritional approach. The possibility is raised of using these approaches synergistically.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91218294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction At any age, functional hypothalamic-pituitary-adrenocortical (HPA) axis is essential for the maintenance of homeostasis during physiologic and stressful (illness) states [1-4]. Though the mechanisms of elevated serum cortisol in maintaining body milieu under these conditions remain unclear, even relative cortisol insufficiency leads to hypoglycemia, hypotension, shock and even death [1-8]. Relative adrenal insufficiency (RAI) occurs when serum cortisol concentration does not increase appropriately in response to stress or illness [1-10]. The definition of RAI in ill adults is a random serum cortisol of <15 μg/dl or an increase of less than 9 μg/dl in response to exogenous ACTH stimulation [26]. The incidence of RAI varies from 5 to 50% in adults, children and neonates with other critical illnesses [2-8].
{"title":"Relative Adrenal Insufficiency (RAI): Unrecognized in Neonates with Cyanotic Congenital Heart Disease","authors":"Monica Sondhi, J. Tran, I. Purdy, U. Devaskar","doi":"10.33425/2689-1085.1027","DOIUrl":"https://doi.org/10.33425/2689-1085.1027","url":null,"abstract":"Introduction At any age, functional hypothalamic-pituitary-adrenocortical (HPA) axis is essential for the maintenance of homeostasis during physiologic and stressful (illness) states [1-4]. Though the mechanisms of elevated serum cortisol in maintaining body milieu under these conditions remain unclear, even relative cortisol insufficiency leads to hypoglycemia, hypotension, shock and even death [1-8]. Relative adrenal insufficiency (RAI) occurs when serum cortisol concentration does not increase appropriately in response to stress or illness [1-10]. The definition of RAI in ill adults is a random serum cortisol of <15 μg/dl or an increase of less than 9 μg/dl in response to exogenous ACTH stimulation [26]. The incidence of RAI varies from 5 to 50% in adults, children and neonates with other critical illnesses [2-8].","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85000886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevention of Cytomegalovirus (CMV) Transmission via Maternal Breast Milk to an Infant with Severe Combined Immunodeficiency (SCID) using Kimie: New Compact Breast Milk Pasteurizer","authors":"L. Kohn, H. Horowitz, M. Butte, U. Devaskar","doi":"10.33425/2689-1085.1025","DOIUrl":"https://doi.org/10.33425/2689-1085.1025","url":null,"abstract":"Abbreviations BM: Breast milk, CMV: Cytomegalovirus, DBM: Donor breast milk. DBMB: Donor breast milk bank, EBM: Expressed breast milk. GA: Gestational AG, HSCT: Hematopoietic stem cell transplantation, MBM: Maternal breast milk, NBS: Newborn screening, NICU: Neonatal Intensive Care Unit, PBM: Pasteurized breast milk, PDBM: Pasteurized donor breast milk, SCID: Severe Combined Immuno-Deficiency, TREC: T-cell recombination excision circle.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74635871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The postpartum period is attended by numerous variations in women's health and quality of life. These alterations can affect the health of mothers and children. Considering the importance of postnatal quality of life and its different contributing factors, this study aimed to compare women’s quality of life after vaginal delivery and cesarean section. Aim: This study was aimed to assess the relationship between mode of birth and quality of life for women's health during the postpartum period. Methods: The study was conducted at the Erebouni medical center of Armenia. The participants’ quality of life was examined, using Short Form-36 (SF-36) questionnaire, evaluating three periods of time including 3, 6 and 12 months after delivery (either vaginal or cesarean delivery). Data were analyzed using t-test. Questions were about pain intensity, frequency, and location, as well as medical treatment and impact on daily living. Study design: A descriptive study design was used in the current study. Study sample: A total of 100 women attended the outpatient clinic using a purposive sample. Data collection Tools: The data have been collected a structured interview questionnaire and a SF-36 form in order to assess the women`s life quality used a purposive sample method. The study carried out from May 2020 to June 2021. Results: The mean age of women was 26.3 ± 2.2 years and 26.3 ± 7.51 years of the caesarean and vaginal birth group, respectively. Quality of life was significantly higher in women with vaginal delivery, compared to women with cesarean section in all periods including three months (93.7 ± 11.2 vs. 50.4 ± 12.7), six months (94.2 ± 14.5 vs. 65.1 ± 12.3), and one year (106.9 ± 10.5 vs. 63.9 ± 9.6) after delivery. Conclusion & Recommendation: According to the study results, the vaginal birth group had higher scores of SF36 compared to caesarean delivery. Thus, vaginal birth is the safe and less expensive option choice for mothers and their family, if there were no indications of caesarean delivery.
{"title":"Quality of Life in Women after Vaginal Delivery and Cesarean Section in Armenia","authors":"G. N.","doi":"10.33425/2689-1085.1028","DOIUrl":"https://doi.org/10.33425/2689-1085.1028","url":null,"abstract":"Background: The postpartum period is attended by numerous variations in women's health and quality of life. These alterations can affect the health of mothers and children. Considering the importance of postnatal quality of life and its different contributing factors, this study aimed to compare women’s quality of life after vaginal delivery and cesarean section. Aim: This study was aimed to assess the relationship between mode of birth and quality of life for women's health during the postpartum period. Methods: The study was conducted at the Erebouni medical center of Armenia. The participants’ quality of life was examined, using Short Form-36 (SF-36) questionnaire, evaluating three periods of time including 3, 6 and 12 months after delivery (either vaginal or cesarean delivery). Data were analyzed using t-test. Questions were about pain intensity, frequency, and location, as well as medical treatment and impact on daily living. Study design: A descriptive study design was used in the current study. Study sample: A total of 100 women attended the outpatient clinic using a purposive sample. Data collection Tools: The data have been collected a structured interview questionnaire and a SF-36 form in order to assess the women`s life quality used a purposive sample method. The study carried out from May 2020 to June 2021. Results: The mean age of women was 26.3 ± 2.2 years and 26.3 ± 7.51 years of the caesarean and vaginal birth group, respectively. Quality of life was significantly higher in women with vaginal delivery, compared to women with cesarean section in all periods including three months (93.7 ± 11.2 vs. 50.4 ± 12.7), six months (94.2 ± 14.5 vs. 65.1 ± 12.3), and one year (106.9 ± 10.5 vs. 63.9 ± 9.6) after delivery. Conclusion & Recommendation: According to the study results, the vaginal birth group had higher scores of SF36 compared to caesarean delivery. Thus, vaginal birth is the safe and less expensive option choice for mothers and their family, if there were no indications of caesarean delivery.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77616053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simone P. Fernandes, Janine Alessi, Mirian Benites Machado, Zilda Elisabeth de Albuquerque Santos, C. A. Nogueira‐de‐Almeida, E. D. de Mello
Objective: To evaluate serum PYY levels in obese adolescents treated in an outpatient obesity treatment program at a public hospital in southern Brazil. Methods: Fifty-one adolescents with obesity were included and followed up for 12 months. They attended 12 consultations with weight loss recommendations based on quantitative and qualitative food goals and reduction of sedentary behavior. Fasting serum levels of PYY, total cholesterol, HDL-cholesterol, triglycerides (TG), LDLcholesterol (LDL-C), insulin and glycemia were collected in T0 (before the first consultation), T1 (after 24 weeks) and T2 (after 48 weeks). Besides blood samples, abdominal circumference (AC) was measured, and the homeostasis model assessment (HOMA-IR) was calculated. By electrical bioimpedance analysis, fat mass and basal metabolic rate were measured. Results: Between T0 and T2, there was weight loss with a significant reduction of body mass index (BMI) Z-scores (p<0.001). There were also a significat reduction of PYY (p=0.026), TRIG (p=0.016), LDL-C (p=0.016), HOMAIR (p=0.004), AC (p<0.001) and BMI (p=0.002). In T2, there was a reduction in the baseline weight and in the proportion of severe obesity, and there was an increase in PYY levels (r=-0.421; p=0.002). Conclusion: Obese adolescents who changed their sedentary behavior and adopted a balanced diet showed weight loss and increse in PYY levels.
{"title":"Plasma Levels of Peptide YY in Obese Adolescents Throughout A Year of Treatment for Weight Loss","authors":"Simone P. Fernandes, Janine Alessi, Mirian Benites Machado, Zilda Elisabeth de Albuquerque Santos, C. A. Nogueira‐de‐Almeida, E. D. de Mello","doi":"10.33425/2689-1085.1026","DOIUrl":"https://doi.org/10.33425/2689-1085.1026","url":null,"abstract":"Objective: To evaluate serum PYY levels in obese adolescents treated in an outpatient obesity treatment program at a public hospital in southern Brazil. Methods: Fifty-one adolescents with obesity were included and followed up for 12 months. They attended 12 consultations with weight loss recommendations based on quantitative and qualitative food goals and reduction of sedentary behavior. Fasting serum levels of PYY, total cholesterol, HDL-cholesterol, triglycerides (TG), LDLcholesterol (LDL-C), insulin and glycemia were collected in T0 (before the first consultation), T1 (after 24 weeks) and T2 (after 48 weeks). Besides blood samples, abdominal circumference (AC) was measured, and the homeostasis model assessment (HOMA-IR) was calculated. By electrical bioimpedance analysis, fat mass and basal metabolic rate were measured. Results: Between T0 and T2, there was weight loss with a significant reduction of body mass index (BMI) Z-scores (p<0.001). There were also a significat reduction of PYY (p=0.026), TRIG (p=0.016), LDL-C (p=0.016), HOMAIR (p=0.004), AC (p<0.001) and BMI (p=0.002). In T2, there was a reduction in the baseline weight and in the proportion of severe obesity, and there was an increase in PYY levels (r=-0.421; p=0.002). Conclusion: Obese adolescents who changed their sedentary behavior and adopted a balanced diet showed weight loss and increse in PYY levels.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90632075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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