硬膜外布托啡诺与硬膜外芬太尼对下肢骨科手术术后疼痛缓解的比较研究。

Pooja Mannela, Srinivas Pamarthi
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引用次数: 0

摘要

背景:芬太尼和吗啡等硬膜外麻醉激动剂已被研究作为布比卡因术中和术后硬膜外镇痛的辅助剂。副作用如瘙痒、恶心、呕吐、呼吸抑制和尿潴留。对无副作用或低副作用的有效镇痛药的研究仍在继续。目的和目的:评价布托啡诺和芬太尼硬膜外给药两组患者的麻醉起效、镇痛持续时间。观察并比较两组术后不良反应。材料与方法:我们将60例骨科骨折(下肢)患者分为两组,每组30例,采用imil髓内钉治疗股骨和胫骨。手术采用CSE技术,A组给予布托啡诺,B组给予芬太尼辅助。记录各组镇痛的起效、持续时间及不良反应。结果:芬太尼组镇痛起效快(3.26+/- 0.95),布托啡诺组起效快(6.54 +/-1.10)。布托啡诺组镇痛时间(330 +/- 62分钟)较芬太尼组(210 +/- 32分钟)更长。布托啡诺组镇痛质量(80%)优于芬太尼组(43%)。结论:芬太尼硬膜外镇痛起效快。布托啡诺硬膜外镇痛时间长,镇痛质量好。与芬太尼相比,硬膜外布托啡诺的副作用更少。
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A Comparative Study of Epidural Butorphanol and Epidural Fentanyl for Postoperative pain relief in Lower Limb Orthopaedic Surgeries.
Background: Epidural narcotic agonists like fentanyl, and morphine has been studied as an adjunct to Bupivacaine for intraoperative and to provide epidural postoperative analgesia. Side effects like pruritus, nausea, vomiting, respiratory depression, and urinary retention occur with their use. The search for an effective analgesic with no or low incidence of side effects is continuing. Aims and objective: To evaluate the onset of anaesthesia, duration of analgesia with epidural administration of Butorphanol and fentanyl in 2 groups. Observe and compare side effects between these groups during post-operative period. Material and Methods: We had done this study on 60 patients with Orthopaedic fractures (lowerlimb), which are treated with IM IL nailing femur and tibia distributed to two groups of 30 each. Surgery was done under CSE technique, with Group A receiving butorphanol and Group B Fentanyl as adjuvant. The onset, duration of analgesia and side effects were recorded in each group. Results: The onset of analgesia was rapid in Fentanyl group (3.26+/- 0.95) than Butorphanol group (6.54 +/-1.10). Duration of analgesia was longer in Butorphanol group (330 +/- 62 minutes) in comparison to Fentanyl group (210 +/- 32 minutes). Quality of analgesia is better in Butorphanol group (80%) than Fentanyl group (43 %). Side effects were more in Group B than Group A. Conclusion: Epidural Fentanyl has faster onset of analgesia. Epidural Butorphanol has longer duration of analgesia with better quality of analgesia. Epidural butorphanol has fewer side effects when compared to Fentanyl.
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